Neurohumoral control of esophageal epithelial electrolyte transport

D. D. Boyd, C. N. Carney, D. W. Powell

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The neurohumoral control of epithelial esophageal electrolyte transport was investigated by studying the effect of various hormones and neuroeffector agents on the potential difference (PD) in vivo or on the electrical parameters or electrolyte transport in vitro. The rabbit esophagus, which has no submucosal esophageal glands, demonstrated no effect of pentagastrin, cholecystokinin octapeptide, or synthetic secretin in vivo, and no effect of these hormones or of vasopressin, aldosterone, carbachol, epinephrine, or cAMP in vitro. The rabbit esophagus did not respond to metabolic substrates (glucose) in vitro by increasing sodium absorption. In contrast, the opossum esophagus, which contains extensive submucosal glands, had a lower electrical resistance, PD, short-circuit current, and sodium absorption with higher chloride secretion. This esophagus responded to carbachol and epinephrine by sodium and chloride secretion. We believe that only the submucosal glands of the esophagus are under significant neurohumoral control while the sodium transporting function of the stratified squamous epithelium of this organ is important in maintaining its barrier function.

Original languageEnglish (US)
Pages (from-to)5-11
Number of pages7
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume2
Issue number1
StatePublished - 1980
Externally publishedYes

Fingerprint

Electrolytes
Esophagus
Sodium
Carbachol
Epinephrine
Hormones
Rabbits
Opossums
Sincalide
Pentagastrin
Secretin
Aldosterone
Vasopressins
Electric Impedance
Sodium Chloride
Chlorides
Epithelium
Glucose
In Vitro Techniques

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Neurohumoral control of esophageal epithelial electrolyte transport. / Boyd, D. D.; Carney, C. N.; Powell, D. W.

In: American Journal of Physiology - Gastrointestinal and Liver Physiology, Vol. 2, No. 1, 1980, p. 5-11.

Research output: Contribution to journalArticle

@article{bf359fd069634afba5c8f73a350706a5,
title = "Neurohumoral control of esophageal epithelial electrolyte transport",
abstract = "The neurohumoral control of epithelial esophageal electrolyte transport was investigated by studying the effect of various hormones and neuroeffector agents on the potential difference (PD) in vivo or on the electrical parameters or electrolyte transport in vitro. The rabbit esophagus, which has no submucosal esophageal glands, demonstrated no effect of pentagastrin, cholecystokinin octapeptide, or synthetic secretin in vivo, and no effect of these hormones or of vasopressin, aldosterone, carbachol, epinephrine, or cAMP in vitro. The rabbit esophagus did not respond to metabolic substrates (glucose) in vitro by increasing sodium absorption. In contrast, the opossum esophagus, which contains extensive submucosal glands, had a lower electrical resistance, PD, short-circuit current, and sodium absorption with higher chloride secretion. This esophagus responded to carbachol and epinephrine by sodium and chloride secretion. We believe that only the submucosal glands of the esophagus are under significant neurohumoral control while the sodium transporting function of the stratified squamous epithelium of this organ is important in maintaining its barrier function.",
author = "Boyd, {D. D.} and Carney, {C. N.} and Powell, {D. W.}",
year = "1980",
language = "English (US)",
volume = "2",
pages = "5--11",
journal = "American Journal of Physiology - Endocrinology and Metabolism",
issn = "0193-1849",
publisher = "American Physiological Society",
number = "1",

}

TY - JOUR

T1 - Neurohumoral control of esophageal epithelial electrolyte transport

AU - Boyd, D. D.

AU - Carney, C. N.

AU - Powell, D. W.

PY - 1980

Y1 - 1980

N2 - The neurohumoral control of epithelial esophageal electrolyte transport was investigated by studying the effect of various hormones and neuroeffector agents on the potential difference (PD) in vivo or on the electrical parameters or electrolyte transport in vitro. The rabbit esophagus, which has no submucosal esophageal glands, demonstrated no effect of pentagastrin, cholecystokinin octapeptide, or synthetic secretin in vivo, and no effect of these hormones or of vasopressin, aldosterone, carbachol, epinephrine, or cAMP in vitro. The rabbit esophagus did not respond to metabolic substrates (glucose) in vitro by increasing sodium absorption. In contrast, the opossum esophagus, which contains extensive submucosal glands, had a lower electrical resistance, PD, short-circuit current, and sodium absorption with higher chloride secretion. This esophagus responded to carbachol and epinephrine by sodium and chloride secretion. We believe that only the submucosal glands of the esophagus are under significant neurohumoral control while the sodium transporting function of the stratified squamous epithelium of this organ is important in maintaining its barrier function.

AB - The neurohumoral control of epithelial esophageal electrolyte transport was investigated by studying the effect of various hormones and neuroeffector agents on the potential difference (PD) in vivo or on the electrical parameters or electrolyte transport in vitro. The rabbit esophagus, which has no submucosal esophageal glands, demonstrated no effect of pentagastrin, cholecystokinin octapeptide, or synthetic secretin in vivo, and no effect of these hormones or of vasopressin, aldosterone, carbachol, epinephrine, or cAMP in vitro. The rabbit esophagus did not respond to metabolic substrates (glucose) in vitro by increasing sodium absorption. In contrast, the opossum esophagus, which contains extensive submucosal glands, had a lower electrical resistance, PD, short-circuit current, and sodium absorption with higher chloride secretion. This esophagus responded to carbachol and epinephrine by sodium and chloride secretion. We believe that only the submucosal glands of the esophagus are under significant neurohumoral control while the sodium transporting function of the stratified squamous epithelium of this organ is important in maintaining its barrier function.

UR - http://www.scopus.com/inward/record.url?scp=0018971958&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018971958&partnerID=8YFLogxK

M3 - Article

VL - 2

SP - 5

EP - 11

JO - American Journal of Physiology - Endocrinology and Metabolism

JF - American Journal of Physiology - Endocrinology and Metabolism

SN - 0193-1849

IS - 1

ER -