Neuroimmunomodulation by calcineurin in aging and Alzheimer's disease

Lindsay C. Reese, Giulio Taglialatela

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is a progressive, age-related neurodegenerative disorder which first manifests as profound memory dysfunction. The majority of cases are idiopathic, although advanced age is the greatest risk factor for AD. Recent evidence suggests that pre-fibrillar soluble amyloid-beta (Aβ) underlies an early, progressive loss of synapses that is a hallmark of AD. One of the downstream effects mediated by soluble Aβ aggregates is the hyperactivation of the phosphatase calcineurin (CaN). This important phosphatase is abundant in the nervous system and intimately involved in the mechanisms of memory as well as the immune response. Such a duality places CaN at the crux of neuroimmunomodulation processes. In the present review, we briefly summarize the role of CaN in physiological aging and discuss how CaN hyperactivity could cause the memory impairment, neuroinflammation, and neuronal death that are pathological mechanisms of AD.

Original languageEnglish (US)
Pages (from-to)245-253
Number of pages9
JournalAging and Disease
Volume1
Issue number3
StatePublished - 2010

Fingerprint

Neuroimmunomodulation
Calcineurin
Alzheimer Disease
Phosphoric Monoester Hydrolases
Amyloid
Neurodegenerative Diseases
Synapses
Nervous System

Keywords

  • Alzheimer's
  • Amyloid beta
  • Calcineurin
  • Inflammation
  • Neurodegeneration

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cell Biology
  • Clinical Neurology
  • Pathology and Forensic Medicine

Cite this

Neuroimmunomodulation by calcineurin in aging and Alzheimer's disease. / Reese, Lindsay C.; Taglialatela, Giulio.

In: Aging and Disease, Vol. 1, No. 3, 2010, p. 245-253.

Research output: Contribution to journalArticle

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