Neuroma formation and numbers of axons in a rat model of experimental peripheral neuropathy

Susan M. Carlton; Patrick M. Dougherty; Carolyn M. Pover; Richard E. Coggeshall

doi:10.1016/0304-3940(91)90343-R

Neuroma formation and numbers of axons in a rat model of experimental peripheral neuropathy

Susan M. Carlton, Patrick M. Dougherty, Carolyn M. Pover, Richard E. Coggeshall

Neurobiology

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139 Scopus citations

Abstract

Two weeks following chronic partial constriction of rat sciatic nerve, the perineurium was disrupted and a neuroma had formed at the constriction site in all nerves (n = 5). Axon counts demonstrated an 84-99% and a 62-84% decrease in myelinated and unmyelinated axons respectively, distal to the lesion. Distally, the majority of surviving myelinated axons had diameters of less than 5.0 μm. There was considerable disparity in fiber loss from animal to animal, but similar behavioral changes were demonstrated by all animals. These results are discussed with reference to previously published data and possible mechanisms underlying the behavioral manifestations of this neuropathy model.

Original language	English (US)
Pages (from-to)	88-92
Number of pages	5
Journal	Neuroscience Letters
Volume	131
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(91)90343-R
State	Published - Sep 30 1991

Keywords

Hyperalgesia
Partial nerve constriction
Peripheral nerve
Rat

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(91)90343-R

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abstract = "Two weeks following chronic partial constriction of rat sciatic nerve, the perineurium was disrupted and a neuroma had formed at the constriction site in all nerves (n = 5). Axon counts demonstrated an 84-99% and a 62-84% decrease in myelinated and unmyelinated axons respectively, distal to the lesion. Distally, the majority of surviving myelinated axons had diameters of less than 5.0 μm. There was considerable disparity in fiber loss from animal to animal, but similar behavioral changes were demonstrated by all animals. These results are discussed with reference to previously published data and possible mechanisms underlying the behavioral manifestations of this neuropathy model.",

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AU - Carlton, Susan M.

AU - Dougherty, Patrick M.

AU - Pover, Carolyn M.

AU - Coggeshall, Richard E.

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AB - Two weeks following chronic partial constriction of rat sciatic nerve, the perineurium was disrupted and a neuroma had formed at the constriction site in all nerves (n = 5). Axon counts demonstrated an 84-99% and a 62-84% decrease in myelinated and unmyelinated axons respectively, distal to the lesion. Distally, the majority of surviving myelinated axons had diameters of less than 5.0 μm. There was considerable disparity in fiber loss from animal to animal, but similar behavioral changes were demonstrated by all animals. These results are discussed with reference to previously published data and possible mechanisms underlying the behavioral manifestations of this neuropathy model.

KW - Hyperalgesia

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Neuroma formation and numbers of axons in a rat model of experimental peripheral neuropathy

Abstract

Keywords

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