Neuroma formation and numbers of axons in a rat model of experimental peripheral neuropathy

Susan M. Carlton, Patrick M. Dougherty, Carolyn M. Pover, Richard E. Coggeshall

    Research output: Contribution to journalArticle

    134 Citations (Scopus)

    Abstract

    Two weeks following chronic partial constriction of rat sciatic nerve, the perineurium was disrupted and a neuroma had formed at the constriction site in all nerves (n = 5). Axon counts demonstrated an 84-99% and a 62-84% decrease in myelinated and unmyelinated axons respectively, distal to the lesion. Distally, the majority of surviving myelinated axons had diameters of less than 5.0 μm. There was considerable disparity in fiber loss from animal to animal, but similar behavioral changes were demonstrated by all animals. These results are discussed with reference to previously published data and possible mechanisms underlying the behavioral manifestations of this neuropathy model.

    Original languageEnglish (US)
    Pages (from-to)88-92
    Number of pages5
    JournalNeuroscience Letters
    Volume131
    Issue number1
    DOIs
    StatePublished - Sep 30 1991

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    Neuroma
    Peripheral Nervous System Diseases
    Axons
    Theoretical Models
    Constriction
    Sciatic Nerve
    Peripheral Nerves

    Keywords

    • Hyperalgesia
    • Partial nerve constriction
    • Peripheral nerve
    • Rat

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Neuroma formation and numbers of axons in a rat model of experimental peripheral neuropathy. / Carlton, Susan M.; Dougherty, Patrick M.; Pover, Carolyn M.; Coggeshall, Richard E.

    In: Neuroscience Letters, Vol. 131, No. 1, 30.09.1991, p. 88-92.

    Research output: Contribution to journalArticle

    Carlton, Susan M. ; Dougherty, Patrick M. ; Pover, Carolyn M. ; Coggeshall, Richard E. / Neuroma formation and numbers of axons in a rat model of experimental peripheral neuropathy. In: Neuroscience Letters. 1991 ; Vol. 131, No. 1. pp. 88-92.
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