Neuronal lesions and behavioral modifications in rat following cerebral ischemia and reperfusion

G. Martinez; M. L. Carnazza; C. Di Giacomo; V. Sorrenti; R. Castana; G. Pennisi; J. R. Perez-Polo; A. Vanella

doi:10.1007/BF02527723

Neuronal lesions and behavioral modifications in rat following cerebral ischemia and reperfusion

G. Martinez, M. L. Carnazza, C. Di Giacomo, V. Sorrenti, R. Castana, G. Pennisi, J. R. Perez-Polo, A. Vanella

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Neurons of the mammalian CNS differ in their vulnerability to various disease processes and other insults, particularly in their response to total anoxia/ischemia. In this study we have tested the histological and behavioral modifications induced by experimental conditions of partial cerebral ischemia in the rats. The specific morphological and histological alterations, observed in our experimental conditions of reversible partial cerebral ischemia, confirm the selective vulnerability of certain neuronal populations to ischemic injury and are also evidenced by behavioral modifications which may mirror the functional impairment observed in humans after a transitory ischemic attack.

Original language	English (US)
Pages (from-to)	667-674
Number of pages	8
Journal	Neurochemical Research
Volume	21
Issue number	6
DOIs	https://doi.org/10.1007/BF02527723
State	Published - Jun 1 1996

Keywords

Cerebral ischemia
behavior
neuronal lesions
reperfusion

ASJC Scopus subject areas

Biochemistry
Cellular and Molecular Neuroscience

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10.1007/BF02527723

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AU - Martinez, G.

AU - Carnazza, M. L.

AU - Di Giacomo, C.

AU - Sorrenti, V.

AU - Castana, R.

AU - Pennisi, G.

AU - Perez-Polo, J. R.

AU - Vanella, A.

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KW - Cerebral ischemia

KW - behavior

KW - neuronal lesions

KW - reperfusion

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