Neuronal lesions and behavioral modifications in rat following cerebral ischemia and reperfusion

G. Martinez, M. L. Carnazza, C. Di Giacomo, V. Sorrenti, R. Castana, G. Pennisi, J. R. Perez-Polo, A. Vanella

    Research output: Contribution to journalArticlepeer-review

    10 Scopus citations

    Abstract

    Neurons of the mammalian CNS differ in their vulnerability to various disease processes and other insults, particularly in their response to total anoxia/ischemia. In this study we have tested the histological and behavioral modifications induced by experimental conditions of partial cerebral ischemia in the rats. The specific morphological and histological alterations, observed in our experimental conditions of reversible partial cerebral ischemia, confirm the selective vulnerability of certain neuronal populations to ischemic injury and are also evidenced by behavioral modifications which may mirror the functional impairment observed in humans after a transitory ischemic attack.

    Original languageEnglish (US)
    Pages (from-to)667-674
    Number of pages8
    JournalNeurochemical Research
    Volume21
    Issue number6
    DOIs
    StatePublished - Jun 1 1996

    Keywords

    • Cerebral ischemia
    • behavior
    • neuronal lesions
    • reperfusion

    ASJC Scopus subject areas

    • Biochemistry
    • Cellular and Molecular Neuroscience

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