Neuronal lesions and behavioral modifications in rat following cerebral ischemia and reperfusion

G. Martinez, M. L. Carnazza, C. Di Giacomo, V. Sorrenti, R. Castana, G. Pennisi, J. R. Perez-Polo, A. Vanella

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10 Scopus citations

Abstract

Neurons of the mammalian CNS differ in their vulnerability to various disease processes and other insults, particularly in their response to total anoxia/ischemia. In this study we have tested the histological and behavioral modifications induced by experimental conditions of partial cerebral ischemia in the rats. The specific morphological and histological alterations, observed in our experimental conditions of reversible partial cerebral ischemia, confirm the selective vulnerability of certain neuronal populations to ischemic injury and are also evidenced by behavioral modifications which may mirror the functional impairment observed in humans after a transitory ischemic attack.

Original languageEnglish (US)
Pages (from-to)667-674
Number of pages8
JournalNeurochemical Research
Volume21
Issue number6
DOIs
StatePublished - Jun 1996
Externally publishedYes

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Keywords

  • behavior
  • Cerebral ischemia
  • neuronal lesions
  • reperfusion

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry

Cite this

Martinez, G., Carnazza, M. L., Di Giacomo, C., Sorrenti, V., Castana, R., Pennisi, G., Perez-Polo, J. R., & Vanella, A. (1996). Neuronal lesions and behavioral modifications in rat following cerebral ischemia and reperfusion. Neurochemical Research, 21(6), 667-674. https://doi.org/10.1007/BF02527723