Neuronal soma-satellite glial cell interactions in sensory ganglia and the participation of purinergic receptors

Yanping Gu, Yong Chen, Xiaofei Zhang, Guang Wen Li, Congying Wang, Li-Yen Huang

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

It has been known for some time that the somata of neurons in sensory ganglia respond to electrical or chemical stimulation and release transmitters in a Ca2+-dependent manner. The function of the somatic release has not been well delineated. A unique characteristic of the ganglia is that each neuronal soma is tightly enwrapped by satellite glial cells (SGCs). The somatic membrane of a sensory neuron rarely makes synaptic contact with another neuron. As a result, the influence of somatic release on the activity of adjacent neurons is likely to be indirect and/or slow. Recent studies of neuron-SGC interactions have demonstrated that ATP released from the somata of dorsal root ganglion neurons activates SGCs. They in turn exert complex excitatory and inhibitory modulation of neuronal activity. Thus, SGCs are actively involved in the processing of afferent information. In this review, we summarize our understanding of bidirectional communication between neuronal somata and SGCs in sensory ganglia and its possible role in afferent signaling under normal and injurious conditions. The participation of purinergic receptors is emphasized because of their dominant roles in the communication.

Original languageEnglish (US)
Pages (from-to)53-62
Number of pages10
JournalNeuron Glia Biology
Volume6
Issue number1
DOIs
StatePublished - Feb 2010

Fingerprint

Sensory Ganglia
Purinergic Receptors
Carisoprodol
Cell Communication
Neuroglia
Neurons
Chemical Stimulation
Spinal Ganglia
Sensory Receptor Cells
Automatic Data Processing
Ganglia
Electric Stimulation
Adenosine Triphosphate
Membranes

Keywords

  • cytokine release
  • dorsal root ganglia
  • PX receptor
  • pathological nociception
  • Somatic ATP release

ASJC Scopus subject areas

  • Cell Biology
  • Cellular and Molecular Neuroscience

Cite this

Neuronal soma-satellite glial cell interactions in sensory ganglia and the participation of purinergic receptors. / Gu, Yanping; Chen, Yong; Zhang, Xiaofei; Li, Guang Wen; Wang, Congying; Huang, Li-Yen.

In: Neuron Glia Biology, Vol. 6, No. 1, 02.2010, p. 53-62.

Research output: Contribution to journalArticle

Gu, Yanping ; Chen, Yong ; Zhang, Xiaofei ; Li, Guang Wen ; Wang, Congying ; Huang, Li-Yen. / Neuronal soma-satellite glial cell interactions in sensory ganglia and the participation of purinergic receptors. In: Neuron Glia Biology. 2010 ; Vol. 6, No. 1. pp. 53-62.
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