Neuropathogenesis of Chikungunya infection

astrogliosis and innate immune activation

Fiona M. Inglis, Kim M. Lee, Kevin B. Chiu, Olivia M. Purcell, Peter J. Didier, Kasi Russell-Lodrigue, Scott Weaver, Chad J. Roy, Andrew G. MacLean

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Chikungunya, “that which bends up” in the Makonde dialect, is an emerging global health threat, with increasing incidence of neurological complications. Until 2013, Chikungunya infection had been largely restricted to East Africa and the Indian Ocean, with cases within the USA reported to be from foreign travel. However, in 2014, over 1 million suspected cases were reported in the Americas, and a recently infected human could serve as an unwitting reservoir for the virus resulting in an epidemic in the continental USA. Chikungunya infection is increasingly being associated with neurological sequelae. In this study, we sought to understand the role of astrocytes in the neuropathogenesis of Chikungunya infection. Even after virus has been cleared form the circulation, astrocytes were activated with regard to TLR2 expression. In addition, white matter astrocytes were hypertrophic, with increased arbor volume in gray matter astrocytes. Combined, these would alter the number and distribution of synapses that each astrocyte would be capable of forming. These results provide the first evidence that Chikungunya infection induces morphometric and innate immune activation of astrocytes in vivo. Perturbed glia-neuron signaling could be a major driving factor in the development of Chikungunya-associated neuropathology.

Original languageEnglish (US)
Pages (from-to)140-148
Number of pages9
JournalJournal of NeuroVirology
Volume22
Issue number2
DOIs
StatePublished - Apr 1 2016

Fingerprint

Astrocytes
Infection
Viruses
Indian Ocean
Eastern Africa
Neuroglia
Synapses
Neurons
Incidence

Keywords

  • Alphavirus
  • Chikungunya
  • Gliosis
  • Morphometry
  • Togavirus
  • Toll-like receptor

ASJC Scopus subject areas

  • Virology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Neurology

Cite this

Inglis, F. M., Lee, K. M., Chiu, K. B., Purcell, O. M., Didier, P. J., Russell-Lodrigue, K., ... MacLean, A. G. (2016). Neuropathogenesis of Chikungunya infection: astrogliosis and innate immune activation. Journal of NeuroVirology, 22(2), 140-148. https://doi.org/10.1007/s13365-015-0378-3

Neuropathogenesis of Chikungunya infection : astrogliosis and innate immune activation. / Inglis, Fiona M.; Lee, Kim M.; Chiu, Kevin B.; Purcell, Olivia M.; Didier, Peter J.; Russell-Lodrigue, Kasi; Weaver, Scott; Roy, Chad J.; MacLean, Andrew G.

In: Journal of NeuroVirology, Vol. 22, No. 2, 01.04.2016, p. 140-148.

Research output: Contribution to journalArticle

Inglis, FM, Lee, KM, Chiu, KB, Purcell, OM, Didier, PJ, Russell-Lodrigue, K, Weaver, S, Roy, CJ & MacLean, AG 2016, 'Neuropathogenesis of Chikungunya infection: astrogliosis and innate immune activation', Journal of NeuroVirology, vol. 22, no. 2, pp. 140-148. https://doi.org/10.1007/s13365-015-0378-3
Inglis FM, Lee KM, Chiu KB, Purcell OM, Didier PJ, Russell-Lodrigue K et al. Neuropathogenesis of Chikungunya infection: astrogliosis and innate immune activation. Journal of NeuroVirology. 2016 Apr 1;22(2):140-148. https://doi.org/10.1007/s13365-015-0378-3
Inglis, Fiona M. ; Lee, Kim M. ; Chiu, Kevin B. ; Purcell, Olivia M. ; Didier, Peter J. ; Russell-Lodrigue, Kasi ; Weaver, Scott ; Roy, Chad J. ; MacLean, Andrew G. / Neuropathogenesis of Chikungunya infection : astrogliosis and innate immune activation. In: Journal of NeuroVirology. 2016 ; Vol. 22, No. 2. pp. 140-148.
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