Neuropsychiatric effects of cocaine: Spect measurements

Bruce L. Miller, Ismael Mena, Robert Giombetti, Javier Villanueva-Meyer, A. H. Djenderedjian

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Cocaine causes serious neurologic and neuropsychiatric complications. Cocaine-induced seizures are common and appear to be due to the local anaesthetic actions of this compound. Cocaine induced stroke has varied mechanisms. With ischemic stroke there is severe vasospasm induced by rises in brain catecholamines. These changes can persist for many weeks and can be demonstrated using single-photon emission computerized tomography (SPECT). In many patients with psychiatric symptoms induced by cocaine may be due to decreases in cerebral blood flow. In cocaine abuse, treatment strategies based on decreasing cerebral vasospasm need to be developed.

Original languageEnglish (US)
Pages (from-to)47-58
Number of pages12
JournalJournal of Addictive Diseases
Issue number4
StatePublished - Dec 9 1992
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Clinical Psychology
  • Psychiatry and Mental health


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