Neuropsychological and physiological correlates of fatigue following traumatic brain injury

Dennis J. Zgaljardic; William J. Durham; Kurt A. Mossberg; Jack Foreman; Keta Joshipura; Brent E. Masel; Randall Urban; Melinda Sheffield-Moore

doi:10.3109/02699052.2014.884242

Neuropsychological and physiological correlates of fatigue following traumatic brain injury

Dennis J. Zgaljardic, William J. Durham, Kurt A. Mossberg, Jack Foreman, Keta Joshipura, Brent E. Masel, Randall Urban, Melinda Sheffield-Moore

Research output: Contribution to journal › Review article › peer-review

28 Scopus citations

Abstract

Background: Fatigue is a common and debilitating phenomenon experienced by individuals with traumatic brain injury (TBI) that can negatively influence rate and extent of functional recovery by reducing participation in brain injury rehabilitation services and increasing maladaptive lifestyle practices. The underlying mechanisms of TBI-related fatigue are not entirely understood and focused research on symptom reduction or prevention is limited. Review: The current review of the literature suggests that the aetiology of TBI-related fatigue can be viewed as a multifactorial and complex model impacting physiological systems (i.e. endocrine, skeletal muscle and cardiorespiratory) that can be directly or indirectly influenced by neuropsychological correlates including cognitive and psychological impairment. Distinguishing central from peripheral fatigue is helpful in this regard. Potential therapeutic strategies and pharmacological agents to help alleviate fatigue in this patient population are discussed.

Original language	English (US)
Pages (from-to)	389-397
Number of pages	9
Journal	Brain Injury
Volume	28
Issue number	4
DOIs	https://doi.org/10.3109/02699052.2014.884242
State	Published - 2014

Keywords

Cardiorespiratory capacity
Fatigue
Growth hormone deficiency
Hypopituitarism
Neuropsychology
Rehabilitation
Skeletal muscle dysfunction
Traumatic brain injury

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Developmental and Educational Psychology
Clinical Neurology

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10.3109/02699052.2014.884242

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title = "Neuropsychological and physiological correlates of fatigue following traumatic brain injury",

abstract = "Background: Fatigue is a common and debilitating phenomenon experienced by individuals with traumatic brain injury (TBI) that can negatively influence rate and extent of functional recovery by reducing participation in brain injury rehabilitation services and increasing maladaptive lifestyle practices. The underlying mechanisms of TBI-related fatigue are not entirely understood and focused research on symptom reduction or prevention is limited. Review: The current review of the literature suggests that the aetiology of TBI-related fatigue can be viewed as a multifactorial and complex model impacting physiological systems (i.e. endocrine, skeletal muscle and cardiorespiratory) that can be directly or indirectly influenced by neuropsychological correlates including cognitive and psychological impairment. Distinguishing central from peripheral fatigue is helpful in this regard. Potential therapeutic strategies and pharmacological agents to help alleviate fatigue in this patient population are discussed.",

keywords = "Cardiorespiratory capacity, Fatigue, Growth hormone deficiency, Hypopituitarism, Neuropsychology, Rehabilitation, Skeletal muscle dysfunction, Traumatic brain injury",

author = "Zgaljardic, {Dennis J.} and Durham, {William J.} and Mossberg, {Kurt A.} and Jack Foreman and Keta Joshipura and Masel, {Brent E.} and Randall Urban and Melinda Sheffield-Moore",

note = "Funding Information: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper. This work was partially funded by the generous support of the Moody Endowment, a grant from the National Cancer Institute (5R01CA127971, to M.S.M.) and a pilot grant (to W.J.D.) from the Claude D. Pepper Older Americans Independence Center (5P30-AG024832, to E. Volpi).",

year = "2014",

doi = "10.3109/02699052.2014.884242",

language = "English (US)",

volume = "28",

pages = "389--397",

journal = "Brain Injury",

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T1 - Neuropsychological and physiological correlates of fatigue following traumatic brain injury

AU - Zgaljardic, Dennis J.

AU - Durham, William J.

AU - Mossberg, Kurt A.

AU - Foreman, Jack

AU - Joshipura, Keta

AU - Masel, Brent E.

AU - Urban, Randall

AU - Sheffield-Moore, Melinda

N1 - Funding Information: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper. This work was partially funded by the generous support of the Moody Endowment, a grant from the National Cancer Institute (5R01CA127971, to M.S.M.) and a pilot grant (to W.J.D.) from the Claude D. Pepper Older Americans Independence Center (5P30-AG024832, to E. Volpi).

PY - 2014

Y1 - 2014

N2 - Background: Fatigue is a common and debilitating phenomenon experienced by individuals with traumatic brain injury (TBI) that can negatively influence rate and extent of functional recovery by reducing participation in brain injury rehabilitation services and increasing maladaptive lifestyle practices. The underlying mechanisms of TBI-related fatigue are not entirely understood and focused research on symptom reduction or prevention is limited. Review: The current review of the literature suggests that the aetiology of TBI-related fatigue can be viewed as a multifactorial and complex model impacting physiological systems (i.e. endocrine, skeletal muscle and cardiorespiratory) that can be directly or indirectly influenced by neuropsychological correlates including cognitive and psychological impairment. Distinguishing central from peripheral fatigue is helpful in this regard. Potential therapeutic strategies and pharmacological agents to help alleviate fatigue in this patient population are discussed.

AB - Background: Fatigue is a common and debilitating phenomenon experienced by individuals with traumatic brain injury (TBI) that can negatively influence rate and extent of functional recovery by reducing participation in brain injury rehabilitation services and increasing maladaptive lifestyle practices. The underlying mechanisms of TBI-related fatigue are not entirely understood and focused research on symptom reduction or prevention is limited. Review: The current review of the literature suggests that the aetiology of TBI-related fatigue can be viewed as a multifactorial and complex model impacting physiological systems (i.e. endocrine, skeletal muscle and cardiorespiratory) that can be directly or indirectly influenced by neuropsychological correlates including cognitive and psychological impairment. Distinguishing central from peripheral fatigue is helpful in this regard. Potential therapeutic strategies and pharmacological agents to help alleviate fatigue in this patient population are discussed.

KW - Cardiorespiratory capacity

KW - Fatigue

KW - Growth hormone deficiency

KW - Hypopituitarism

KW - Neuropsychology

KW - Rehabilitation

KW - Skeletal muscle dysfunction

KW - Traumatic brain injury

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Neuropsychological and physiological correlates of fatigue following traumatic brain injury

Abstract

Keywords

ASJC Scopus subject areas

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