Neurotensin secretion in response to intraduodenal and intraileal administration of fat in dogs.

T. Miyashita, T. Hashimoto, G. Gomez, C. M. Townsend, G. H. Greeley, J. C. Thompson

    Research output: Contribution to journalArticle

    Abstract

    Release of neurotensin from the small intestine in response to administration of fat directly into the duodenum and ileum was examined in conscious dogs. The present results show that: (1) intraduodenal administration of fat causes a diphasic release of neurotensin which is mediated, at least in part, by cholinergic mechanisms, and (2) both a fatty acid (sodium oleate) and a triglyceride, when infused directly into an isolated ileal loop, stimulate a significant release of neurotensin. Our findings indicate that release of neurotensin is triggered by mechanisms originating in the proximal small intestine and by a direct contact of nutrients with the ileal mucosa.

    Original languageEnglish (US)
    Pages (from-to)275-281
    Number of pages7
    JournalBiological Signals
    Volume1
    Issue number5
    StatePublished - Sep 1992

    Fingerprint

    Neurotensin
    Fats
    Dogs
    Small Intestine
    Ileum
    Duodenum
    Cholinergic Agents
    Nutrients
    Mucous Membrane
    Triglycerides
    Fatty Acids
    Food

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

    Cite this

    Miyashita, T., Hashimoto, T., Gomez, G., Townsend, C. M., Greeley, G. H., & Thompson, J. C. (1992). Neurotensin secretion in response to intraduodenal and intraileal administration of fat in dogs. Biological Signals, 1(5), 275-281.

    Neurotensin secretion in response to intraduodenal and intraileal administration of fat in dogs. / Miyashita, T.; Hashimoto, T.; Gomez, G.; Townsend, C. M.; Greeley, G. H.; Thompson, J. C.

    In: Biological Signals, Vol. 1, No. 5, 09.1992, p. 275-281.

    Research output: Contribution to journalArticle

    Miyashita, T, Hashimoto, T, Gomez, G, Townsend, CM, Greeley, GH & Thompson, JC 1992, 'Neurotensin secretion in response to intraduodenal and intraileal administration of fat in dogs.', Biological Signals, vol. 1, no. 5, pp. 275-281.
    Miyashita T, Hashimoto T, Gomez G, Townsend CM, Greeley GH, Thompson JC. Neurotensin secretion in response to intraduodenal and intraileal administration of fat in dogs. Biological Signals. 1992 Sep;1(5):275-281.
    Miyashita, T. ; Hashimoto, T. ; Gomez, G. ; Townsend, C. M. ; Greeley, G. H. ; Thompson, J. C. / Neurotensin secretion in response to intraduodenal and intraileal administration of fat in dogs. In: Biological Signals. 1992 ; Vol. 1, No. 5. pp. 275-281.
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