Neurotensin stimulates pancreatic exocrine secretion in rats

Talaat Khalil, Masaki Fujimura, George H. Greeley, Courtney M. Townsend, James C. Thompson

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Neurotensin (NT) stimulates pancreatic exocrine secretion in dogs and humans. The purpose of this study was to examine the effect of exogenous neurotensin on pancreatic exocrine secretion in rats. Five Sprague-Dawley male rats were prepared with pancreatic, gastric and duodenal fistulas. Bile was shunted into the duodenum in order to collect pure pancreatic juice. 24 h later, neurotensin (0.05, 0.1, 0.2, 0.3, 1.0 nmol/kg) was infused intravenously in a random fashion. Pancreatic juice was collected every 10 min, and the volume was recorded and protein and bicarbonate were measured. Neurotensin stimulated, in a dose-related manner, the pancreatic secretion of water, protein and bicarbonate. Neurotensin may be involved in the physiologic control of pancreatic secretion in rats.

Original languageEnglish (US)
Pages (from-to)279-284
Number of pages6
JournalRegulatory Peptides
Issue number3
StatePublished - Oct 1986
Externally publishedYes


  • bicarbonate
  • fistula
  • protein

ASJC Scopus subject areas

  • Physiology
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience


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