Neurotensin stimulates pancreatic exocrine secretion in rats

Talaat Khalil, Masaki Fujimura, George H. Greeley, Courtney Townsend, James C. Thompson

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Neurotensin (NT) stimulates pancreatic exocrine secretion in dogs and humans. The purpose of this study was to examine the effect of exogenous neurotensin on pancreatic exocrine secretion in rats. Five Sprague-Dawley male rats were prepared with pancreatic, gastric and duodenal fistulas. Bile was shunted into the duodenum in order to collect pure pancreatic juice. 24 h later, neurotensin (0.05, 0.1, 0.2, 0.3, 1.0 nmol/kg) was infused intravenously in a random fashion. Pancreatic juice was collected every 10 min, and the volume was recorded and protein and bicarbonate were measured. Neurotensin stimulated, in a dose-related manner, the pancreatic secretion of water, protein and bicarbonate. Neurotensin may be involved in the physiologic control of pancreatic secretion in rats.

Original languageEnglish (US)
Pages (from-to)279-284
Number of pages6
JournalRegulatory Peptides
Volume15
Issue number3
DOIs
StatePublished - 1986

Fingerprint

Neurotensin
Rats
Pancreatic Juice
Bicarbonates
Gastric Fistula
Duodenum
Bile
Sprague Dawley Rats
Proteins
Dogs
Water

Keywords

  • bicarbonate
  • fistula
  • protein

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Neuroscience(all)

Cite this

Neurotensin stimulates pancreatic exocrine secretion in rats. / Khalil, Talaat; Fujimura, Masaki; Greeley, George H.; Townsend, Courtney; Thompson, James C.

In: Regulatory Peptides, Vol. 15, No. 3, 1986, p. 279-284.

Research output: Contribution to journalArticle

Khalil, T, Fujimura, M, Greeley, GH, Townsend, C & Thompson, JC 1986, 'Neurotensin stimulates pancreatic exocrine secretion in rats', Regulatory Peptides, vol. 15, no. 3, pp. 279-284. https://doi.org/10.1016/0167-0115(86)90069-8
Khalil, Talaat ; Fujimura, Masaki ; Greeley, George H. ; Townsend, Courtney ; Thompson, James C. / Neurotensin stimulates pancreatic exocrine secretion in rats. In: Regulatory Peptides. 1986 ; Vol. 15, No. 3. pp. 279-284.
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