Neurotensin stimulates pancreatic exocrine secretion in rats

Talaat Khalil; Masaki Fujimura; George H. Greeley; Courtney M. Townsend; James C. Thompson

doi:10.1016/0167-0115(86)90069-8

Neurotensin stimulates pancreatic exocrine secretion in rats

Talaat Khalil, Masaki Fujimura, George H. Greeley, Courtney M. Townsend, James C. Thompson

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Neurotensin (NT) stimulates pancreatic exocrine secretion in dogs and humans. The purpose of this study was to examine the effect of exogenous neurotensin on pancreatic exocrine secretion in rats. Five Sprague-Dawley male rats were prepared with pancreatic, gastric and duodenal fistulas. Bile was shunted into the duodenum in order to collect pure pancreatic juice. 24 h later, neurotensin (0.05, 0.1, 0.2, 0.3, 1.0 nmol/kg) was infused intravenously in a random fashion. Pancreatic juice was collected every 10 min, and the volume was recorded and protein and bicarbonate were measured. Neurotensin stimulated, in a dose-related manner, the pancreatic secretion of water, protein and bicarbonate. Neurotensin may be involved in the physiologic control of pancreatic secretion in rats.

Original language	English (US)
Pages (from-to)	279-284
Number of pages	6
Journal	Regulatory Peptides
Volume	15
Issue number	3
DOIs	https://doi.org/10.1016/0167-0115(86)90069-8
State	Published - Oct 1986
Externally published	Yes

Keywords

bicarbonate
fistula
protein

ASJC Scopus subject areas

Physiology
Biochemistry
Endocrinology
Clinical Biochemistry
Cellular and Molecular Neuroscience

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10.1016/0167-0115(86)90069-8

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title = "Neurotensin stimulates pancreatic exocrine secretion in rats",

abstract = "Neurotensin (NT) stimulates pancreatic exocrine secretion in dogs and humans. The purpose of this study was to examine the effect of exogenous neurotensin on pancreatic exocrine secretion in rats. Five Sprague-Dawley male rats were prepared with pancreatic, gastric and duodenal fistulas. Bile was shunted into the duodenum in order to collect pure pancreatic juice. 24 h later, neurotensin (0.05, 0.1, 0.2, 0.3, 1.0 nmol/kg) was infused intravenously in a random fashion. Pancreatic juice was collected every 10 min, and the volume was recorded and protein and bicarbonate were measured. Neurotensin stimulated, in a dose-related manner, the pancreatic secretion of water, protein and bicarbonate. Neurotensin may be involved in the physiologic control of pancreatic secretion in rats.",

keywords = "bicarbonate, fistula, protein",

author = "Talaat Khalil and Masaki Fujimura and Greeley, {George H.} and Townsend, {Courtney M.} and Thompson, {James C.}",

note = "Funding Information: This work was supported by grants from the National Institutes of Health (RO1 AM 15241, PO1 AM 35608, and RCDA 008557), and a grant from the Amencan Cancer Society (PDT-220)",

year = "1986",

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AU - Khalil, Talaat

AU - Fujimura, Masaki

AU - Greeley, George H.

AU - Townsend, Courtney M.

AU - Thompson, James C.

N1 - Funding Information: This work was supported by grants from the National Institutes of Health (RO1 AM 15241, PO1 AM 35608, and RCDA 008557), and a grant from the Amencan Cancer Society (PDT-220)

PY - 1986/10

Y1 - 1986/10

N2 - Neurotensin (NT) stimulates pancreatic exocrine secretion in dogs and humans. The purpose of this study was to examine the effect of exogenous neurotensin on pancreatic exocrine secretion in rats. Five Sprague-Dawley male rats were prepared with pancreatic, gastric and duodenal fistulas. Bile was shunted into the duodenum in order to collect pure pancreatic juice. 24 h later, neurotensin (0.05, 0.1, 0.2, 0.3, 1.0 nmol/kg) was infused intravenously in a random fashion. Pancreatic juice was collected every 10 min, and the volume was recorded and protein and bicarbonate were measured. Neurotensin stimulated, in a dose-related manner, the pancreatic secretion of water, protein and bicarbonate. Neurotensin may be involved in the physiologic control of pancreatic secretion in rats.

AB - Neurotensin (NT) stimulates pancreatic exocrine secretion in dogs and humans. The purpose of this study was to examine the effect of exogenous neurotensin on pancreatic exocrine secretion in rats. Five Sprague-Dawley male rats were prepared with pancreatic, gastric and duodenal fistulas. Bile was shunted into the duodenum in order to collect pure pancreatic juice. 24 h later, neurotensin (0.05, 0.1, 0.2, 0.3, 1.0 nmol/kg) was infused intravenously in a random fashion. Pancreatic juice was collected every 10 min, and the volume was recorded and protein and bicarbonate were measured. Neurotensin stimulated, in a dose-related manner, the pancreatic secretion of water, protein and bicarbonate. Neurotensin may be involved in the physiologic control of pancreatic secretion in rats.

KW - bicarbonate

KW - fistula

KW - protein

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ER -

Neurotensin stimulates pancreatic exocrine secretion in rats

Abstract

Keywords

ASJC Scopus subject areas

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