Neurovascular Complications of Iatrogenic Fusarium solani Meningitis

Nora Strong; Grant Meeks; Sunil A. Sheth; Louise McCullough; Julian A. Villalba; Chunfeng Tan; Andrew Barreto; Audrey Wanger; Michelle McDonald; Peter Kan; Hashem Shaltoni; Jose Campo Maldonado; Victoria Parada; Ameer E. Hassan; Sarah Reagan-Steiner; Tom Chiller; Jeremy A.W. Gold; Dallas J. Smith; Luis Ostrosky-Zeichner

doi:10.1056/NEJMoa2308192

Neurovascular Complications of Iatrogenic Fusarium solani Meningitis

Nora Strong, Grant Meeks, Sunil A. Sheth, Louise McCullough, Julian A. Villalba, Chunfeng Tan, Andrew Barreto, Audrey Wanger, Michelle McDonald, Peter Kan, Hashem Shaltoni, Jose Campo Maldonado, Victoria Parada, Ameer E. Hassan, Sarah Reagan-Steiner, Tom Chiller, Jeremy A.W. Gold, Dallas J. Smith, Luis Ostrosky-Zeichner

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9 Scopus citations

Abstract

A multinational outbreak of nosocomial fusarium meningitis occurred among immunocompetent patients who had undergone surgery with epidural anesthesia in Mexico. The pathogen involved had a high predilection for the brain stem and vertebrobasilar arterial system and was associated with high mortality from vessel injury. Effective treatment options remain limited; in vitro susceptibility testing of the organism suggested that it is resistant to all currently approved antifungal medications in the United States. To highlight the severe complications associated with fusarium infection acquired in this manner, we report data, clinical courses, and outcomes from 13 patients in the outbreak who presented with symptoms after a median delay of 39 days.

Original language	English (US)
Pages (from-to)	522-529
Number of pages	8
Journal	New England Journal of Medicine
Volume	390
Issue number	6
DOIs	https://doi.org/10.1056/NEJMoa2308192
State	Published - Feb 8 2024

ASJC Scopus subject areas

General Medicine

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Strong, N., Meeks, G., Sheth, S. A., McCullough, L., Villalba, J. A., Tan, C., Barreto, A., Wanger, A., McDonald, M., Kan, P., Shaltoni, H., Maldonado, J. C., Parada, V., Hassan, A. E., Reagan-Steiner, S., Chiller, T., Gold, J. A. W., Smith, D. J., & Ostrosky-Zeichner, L. (2024). Neurovascular Complications of Iatrogenic Fusarium solani Meningitis. New England Journal of Medicine, 390(6), 522-529. https://doi.org/10.1056/NEJMoa2308192

Strong, N, Meeks, G, Sheth, SA, McCullough, L, Villalba, JA, Tan, C, Barreto, A, Wanger, A, McDonald, M, Kan, P , Shaltoni, H, Maldonado, JC, Parada, V, Hassan, AE, Reagan-Steiner, S, Chiller, T, Gold, JAW, Smith, DJ & Ostrosky-Zeichner, L 2024, 'Neurovascular Complications of Iatrogenic Fusarium solani Meningitis', New England Journal of Medicine, vol. 390, no. 6, pp. 522-529. https://doi.org/10.1056/NEJMoa2308192

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abstract = "A multinational outbreak of nosocomial fusarium meningitis occurred among immunocompetent patients who had undergone surgery with epidural anesthesia in Mexico. The pathogen involved had a high predilection for the brain stem and vertebrobasilar arterial system and was associated with high mortality from vessel injury. Effective treatment options remain limited; in vitro susceptibility testing of the organism suggested that it is resistant to all currently approved antifungal medications in the United States. To highlight the severe complications associated with fusarium infection acquired in this manner, we report data, clinical courses, and outcomes from 13 patients in the outbreak who presented with symptoms after a median delay of 39 days.",

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Neurovascular Complications of Iatrogenic Fusarium solani Meningitis

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