@article{e641dab3ed834917935ed9bc492dfe17,
title = "Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera",
abstract = "We engineered three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses containing key spike mutations from the newly emerged United Kingdom (UK) and South African (SA) variants: N501Y from UK and SA; 69/70-deletion + N501Y + D614G from UK; and E484K + N501Y + D614G from SA. Neutralization geometric mean titers (GMTs) of 20 BTN162b2 vaccine-elicited human sera against the three mutant viruses were 0.81- to 1.46-fold of the GMTs against parental virus, indicating small effects of these mutations on neutralization by sera elicited by two BNT162b2 doses.",
author = "Xuping Xie and Yang Liu and Jianying Liu and Xianwen Zhang and Jing Zou and Fontes-Garfias, {Camila R.} and Hongjie Xia and Swanson, {Kena A.} and Mark Cutler and David Cooper and Menachery, {Vineet D.} and Weaver, {Scott C.} and Dormitzer, {Philip R.} and Shi, {Pei Yong}",
note = "Funding Information: This work was supported by Pfizer and BioNTech. We thank colleagues at Pfizer, BioNTech and the University of Texas Medical Branch for helpful discussions and support during the study. We thank the Pfizer-BioNTech clinical trial C4591001 participants, from whom the post-immunization human sera were obtained. We thank the many colleagues at Pfizer and BioNTech who developed and produced the BNT162b2 vaccine candidate. P.-Y.S. was supported by National Institutes of Health grants AI142759, AI134907, AI145617 and UL1TR001439, and awards from the Sealy & Smith Foundation, Kleberg Foundation, the John S. Dunn Foundation, the Amon G. Carter Foundation, the Gilson Longenbaugh Foundation and the Summerfield Robert Foundation. Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer Nature America, Inc. part of Springer Nature.",
year = "2021",
month = apr,
doi = "10.1038/s41591-021-01270-4",
language = "English (US)",
volume = "27",
pages = "620--621",
journal = "Nature Medicine",
issn = "1078-8956",
publisher = "Nature Publishing Group",
number = "4",
}