Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera

Xuping Xie; Yang Liu; Jianying Liu; Xianwen Zhang; Jing Zou; Camila R. Fontes-Garfias; Hongjie Xia; Kena A. Swanson; Mark Cutler; David Cooper; Vineet D. Menachery; Scott C. Weaver; Philip R. Dormitzer; Pei Yong Shi

doi:10.1038/s41591-021-01270-4

Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera

Xuping Xie, Yang Liu, Jianying Liu, Xianwen Zhang, Jing Zou, Camila R. Fontes-Garfias, Hongjie Xia, Kena A. Swanson, Mark Cutler, David Cooper, Vineet D. Menachery, Scott C. Weaver, Philip R. Dormitzer, Pei Yong Shi

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415 Scopus citations

Abstract

We engineered three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses containing key spike mutations from the newly emerged United Kingdom (UK) and South African (SA) variants: N501Y from UK and SA; 69/70-deletion + N501Y + D614G from UK; and E484K + N501Y + D614G from SA. Neutralization geometric mean titers (GMTs) of 20 BTN162b2 vaccine-elicited human sera against the three mutant viruses were 0.81- to 1.46-fold of the GMTs against parental virus, indicating small effects of these mutations on neutralization by sera elicited by two BNT162b2 doses.

Original language	English (US)
Pages (from-to)	620-621
Number of pages	2
Journal	Nature Medicine
Volume	27
Issue number	4
DOIs	https://doi.org/10.1038/s41591-021-01270-4
State	Published - Apr 2021

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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Xie, X., Liu, Y., Liu, J., Zhang, X., Zou, J., Fontes-Garfias, C. R., Xia, H., Swanson, K. A., Cutler, M., Cooper, D., Menachery, V. D., Weaver, S. C., Dormitzer, P. R., & Shi, P. Y. (2021). Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera. Nature Medicine, 27(4), 620-621. https://doi.org/10.1038/s41591-021-01270-4

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title = "Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera",

abstract = "We engineered three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses containing key spike mutations from the newly emerged United Kingdom (UK) and South African (SA) variants: N501Y from UK and SA; 69/70-deletion + N501Y + D614G from UK; and E484K + N501Y + D614G from SA. Neutralization geometric mean titers (GMTs) of 20 BTN162b2 vaccine-elicited human sera against the three mutant viruses were 0.81- to 1.46-fold of the GMTs against parental virus, indicating small effects of these mutations on neutralization by sera elicited by two BNT162b2 doses.",

author = "Xuping Xie and Yang Liu and Jianying Liu and Xianwen Zhang and Jing Zou and Fontes-Garfias, {Camila R.} and Hongjie Xia and Swanson, {Kena A.} and Mark Cutler and David Cooper and Menachery, {Vineet D.} and Weaver, {Scott C.} and Dormitzer, {Philip R.} and Shi, {Pei Yong}",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer Nature America, Inc. part of Springer Nature.",

year = "2021",

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doi = "10.1038/s41591-021-01270-4",

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AU - Xie, Xuping

AU - Liu, Yang

AU - Liu, Jianying

AU - Zhang, Xianwen

AU - Zou, Jing

AU - Fontes-Garfias, Camila R.

AU - Xia, Hongjie

AU - Swanson, Kena A.

AU - Cutler, Mark

AU - Cooper, David

AU - Menachery, Vineet D.

AU - Weaver, Scott C.

AU - Dormitzer, Philip R.

AU - Shi, Pei Yong

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AB - We engineered three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses containing key spike mutations from the newly emerged United Kingdom (UK) and South African (SA) variants: N501Y from UK and SA; 69/70-deletion + N501Y + D614G from UK; and E484K + N501Y + D614G from SA. Neutralization geometric mean titers (GMTs) of 20 BTN162b2 vaccine-elicited human sera against the three mutant viruses were 0.81- to 1.46-fold of the GMTs against parental virus, indicating small effects of these mutations on neutralization by sera elicited by two BNT162b2 doses.

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Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera

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