Neutralizing Antibody Immune Correlates for a Recombinant Protein Vaccine in the COVAIL Trial

Coronavirus Variant Immunologic Landscape Trial (COVAIL) Study Team

doi:10.1093/cid/ciae465

Neutralizing Antibody Immune Correlates for a Recombinant Protein Vaccine in the COVAIL Trial

Coronavirus Variant Immunologic Landscape Trial (COVAIL) Study Team

Family Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

For COVAIL recipients of a coronavirus disease 2019 (COVID-19) Sanofi booster vaccine, neutralizing antibody titers were assessed as a correlate of risk (CoR) of COVID-19. Peak and exposure-proximal titers were inverse CoRs with covariate-adjusted hazard ratios (95% confidence intervals) 0.30 (0.11, 0.78) and 0.25 (0.07, 0.85) per 10-fold increase in weighted average titer.

Original language	English (US)
Pages (from-to)	223-227
Number of pages	5
Journal	Clinical Infectious Diseases
Volume	80
Issue number	1
DOIs	https://doi.org/10.1093/cid/ciae465
State	Published - Jan 15 2025

Keywords

COVID-19 booster
Omicron
correlate of risk
exposure-proximal titer
variant vaccine booster

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

Access to Document

10.1093/cid/ciae465

Cite this

@article{06f36e38f55c45bfa1a7b5373294d540,

title = "Neutralizing Antibody Immune Correlates for a Recombinant Protein Vaccine in the COVAIL Trial",

abstract = "For COVAIL recipients of a coronavirus disease 2019 (COVID-19) Sanofi booster vaccine, neutralizing antibody titers were assessed as a correlate of risk (CoR) of COVID-19. Peak and exposure-proximal titers were inverse CoRs with covariate-adjusted hazard ratios (95\% confidence intervals) 0.30 (0.11, 0.78) and 0.25 (0.07, 0.85) per 10-fold increase in weighted average titer.",

keywords = "COVID-19 booster, Omicron, correlate of risk, exposure-proximal titer, variant vaccine booster",

author = "\{Coronavirus Variant Immunologic Landscape Trial (COVAIL) Study Team\} and Youyi Fong and Lauren Dang and Bo Zhang and Jonathan Fintzi and Shiyu Chen and Jing Wang and Rouphael, \{Nadine G.\} and Branche, \{Angela R.\} and Diemert, \{David J.\} and Falsey, \{Ann R.\} and Cecilia Losada and Baden, \{Lindsey R.\} and Frey, \{Sharon E.\} and Whitaker, \{Jennifer A.\} and Little, \{Susan J.\} and Satoshi Kamidani and Walter, \{Emmanuel B.\} and Novak, \{Richard M.\} and Richard Rupp and Jackson, \{Lisa A.\} and Chenchen Yu and Magaret, \{Craig A.\} and Cindy Molitor and Bhavesh Borate and Babu, \{Tara M.\} and Kottkamp, \{Angelica C.\} and Luetkemeyer, \{Anne F.\} and Immergluck, \{Lilly C.\} and Presti, \{Rachel M.\} and Mart{\'i}n B{\"a}cker and Winokur, \{Patricia L.\} and Mahgoub, \{Siham M.\} and Goepfert, \{Paul A.\} and Fusco, \{Dahlene N.\} and Atmar, \{Robert L.\} and Posavad, \{Christine M.\} and Jinjian Mu and Mat Makowski and Makhene, \{Mamodikoe K.\} and Nayak, \{Seema U.\} and Roberts, \{Paul C.\} and Dean Follmann and Gilbert, \{Peter B.\} and Elissa Malkin and Bethony, \{Jeffrey M.\} and Aimee Desrosiers and Marc Siegel and Edward Walsh and Patrick Kingsley and Laura Porterfield",

year = "2025",

month = jan,

day = "15",

doi = "10.1093/cid/ciae465",

language = "English (US)",

volume = "80",

pages = "223--227",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

publisher = "Oxford University Press",

number = "1",

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T1 - Neutralizing Antibody Immune Correlates for a Recombinant Protein Vaccine in the COVAIL Trial

AU - Coronavirus Variant Immunologic Landscape Trial (COVAIL) Study Team

AU - Fong, Youyi

AU - Dang, Lauren

AU - Zhang, Bo

AU - Fintzi, Jonathan

AU - Chen, Shiyu

AU - Wang, Jing

AU - Rouphael, Nadine G.

AU - Branche, Angela R.

AU - Diemert, David J.

AU - Falsey, Ann R.

AU - Losada, Cecilia

AU - Baden, Lindsey R.

AU - Frey, Sharon E.

AU - Whitaker, Jennifer A.

AU - Little, Susan J.

AU - Kamidani, Satoshi

AU - Walter, Emmanuel B.

AU - Novak, Richard M.

AU - Rupp, Richard

AU - Jackson, Lisa A.

AU - Yu, Chenchen

AU - Magaret, Craig A.

AU - Molitor, Cindy

AU - Borate, Bhavesh

AU - Babu, Tara M.

AU - Kottkamp, Angelica C.

AU - Luetkemeyer, Anne F.

AU - Immergluck, Lilly C.

AU - Presti, Rachel M.

AU - Bäcker, Martín

AU - Winokur, Patricia L.

AU - Mahgoub, Siham M.

AU - Goepfert, Paul A.

AU - Fusco, Dahlene N.

AU - Atmar, Robert L.

AU - Posavad, Christine M.

AU - Mu, Jinjian

AU - Makowski, Mat

AU - Makhene, Mamodikoe K.

AU - Nayak, Seema U.

AU - Roberts, Paul C.

AU - Follmann, Dean

AU - Gilbert, Peter B.

AU - Malkin, Elissa

AU - Bethony, Jeffrey M.

AU - Desrosiers, Aimee

AU - Siegel, Marc

AU - Walsh, Edward

AU - Kingsley, Patrick

AU - Porterfield, Laura

PY - 2025/1/15

Y1 - 2025/1/15

N2 - For COVAIL recipients of a coronavirus disease 2019 (COVID-19) Sanofi booster vaccine, neutralizing antibody titers were assessed as a correlate of risk (CoR) of COVID-19. Peak and exposure-proximal titers were inverse CoRs with covariate-adjusted hazard ratios (95% confidence intervals) 0.30 (0.11, 0.78) and 0.25 (0.07, 0.85) per 10-fold increase in weighted average titer.

AB - For COVAIL recipients of a coronavirus disease 2019 (COVID-19) Sanofi booster vaccine, neutralizing antibody titers were assessed as a correlate of risk (CoR) of COVID-19. Peak and exposure-proximal titers were inverse CoRs with covariate-adjusted hazard ratios (95% confidence intervals) 0.30 (0.11, 0.78) and 0.25 (0.07, 0.85) per 10-fold increase in weighted average titer.

KW - COVID-19 booster

KW - Omicron

KW - correlate of risk

KW - exposure-proximal titer

KW - variant vaccine booster

UR - https://www.scopus.com/pages/publications/85218167493

UR - https://www.scopus.com/inward/citedby.url?scp=85218167493&partnerID=8YFLogxK

U2 - 10.1093/cid/ciae465

DO - 10.1093/cid/ciae465

M3 - Article

C2 - 39325506

AN - SCOPUS:85218167493

SN - 1058-4838

VL - 80

SP - 223

EP - 227

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 1

ER -

Neutralizing Antibody Immune Correlates for a Recombinant Protein Vaccine in the COVAIL Trial

Abstract

Keywords

ASJC Scopus subject areas

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