Neutralizing antibody response elicited by SARS-CoV-2 receptor-binding domain

Ping Han Huang; Hsiao Han Tsai; Bo Hung Liao; Yi Ling Lin; Jia Tsrong Jan; Mi Hua Tao; Yu Chi Chou; Che Ming Jack Hu; Hui Wen Chen

doi:10.1080/21645515.2020.1814098

Neutralizing antibody response elicited by SARS-CoV-2 receptor-binding domain

Ping Han Huang, Hsiao Han Tsai, Bo Hung Liao, Yi Ling Lin, Jia Tsrong Jan, Mi Hua Tao, Yu Chi Chou, Che Ming Jack Hu, Hui Wen Chen

Research output: Contribution to journal › Comment/debate › peer-review

5 Scopus citations

Abstract

A safe and effective vaccine candidate is urgently needed for the ongoing COVID-19 pandemic, caused by SARS-CoV-2. Here we report that recombinant SARS-CoV-2 RBD protein immunization in mice is able to elicit a strong antibody response and potent neutralizing capability as measured using live or pseudotyped SARS-CoV-2 neutralization assays.

Original language	English (US)
Pages (from-to)	654-655
Number of pages	2
Journal	Human Vaccines and Immunotherapeutics
Volume	17
Issue number	3
DOIs	https://doi.org/10.1080/21645515.2020.1814098
State	Published - 2021
Externally published	Yes

Keywords

SARS-CoV-2
neutralizing antibodies
receptor-binding domain
vaccine

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Pharmacology

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10.1080/21645515.2020.1814098

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title = "Neutralizing antibody response elicited by SARS-CoV-2 receptor-binding domain",

abstract = "A safe and effective vaccine candidate is urgently needed for the ongoing COVID-19 pandemic, caused by SARS-CoV-2. Here we report that recombinant SARS-CoV-2 RBD protein immunization in mice is able to elicit a strong antibody response and potent neutralizing capability as measured using live or pseudotyped SARS-CoV-2 neutralization assays.",

keywords = "SARS-CoV-2, neutralizing antibodies, receptor-binding domain, vaccine",

author = "Huang, {Ping Han} and Tsai, {Hsiao Han} and Liao, {Bo Hung} and Lin, {Yi Ling} and Jan, {Jia Tsrong} and Tao, {Mi Hua} and Chou, {Yu Chi} and Hu, {Che Ming Jack} and Chen, {Hui Wen}",

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year = "2021",

doi = "10.1080/21645515.2020.1814098",

language = "English (US)",

volume = "17",

pages = "654--655",

journal = "Human Vaccines and Immunotherapeutics",

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TY - JOUR

T1 - Neutralizing antibody response elicited by SARS-CoV-2 receptor-binding domain

AU - Huang, Ping Han

AU - Tsai, Hsiao Han

AU - Liao, Bo Hung

AU - Lin, Yi Ling

AU - Jan, Jia Tsrong

AU - Tao, Mi Hua

AU - Chou, Yu Chi

AU - Hu, Che Ming Jack

AU - Chen, Hui Wen

PY - 2021

Y1 - 2021

N2 - A safe and effective vaccine candidate is urgently needed for the ongoing COVID-19 pandemic, caused by SARS-CoV-2. Here we report that recombinant SARS-CoV-2 RBD protein immunization in mice is able to elicit a strong antibody response and potent neutralizing capability as measured using live or pseudotyped SARS-CoV-2 neutralization assays.

AB - A safe and effective vaccine candidate is urgently needed for the ongoing COVID-19 pandemic, caused by SARS-CoV-2. Here we report that recombinant SARS-CoV-2 RBD protein immunization in mice is able to elicit a strong antibody response and potent neutralizing capability as measured using live or pseudotyped SARS-CoV-2 neutralization assays.

KW - SARS-CoV-2

KW - neutralizing antibodies

KW - receptor-binding domain

KW - vaccine

UR - http://www.scopus.com/inward/record.url?scp=85091731587&partnerID=8YFLogxK

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U2 - 10.1080/21645515.2020.1814098

DO - 10.1080/21645515.2020.1814098

M3 - Comment/debate

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AN - SCOPUS:85091731587

SN - 2164-5515

VL - 17

SP - 654

EP - 655

JO - Human Vaccines and Immunotherapeutics

JF - Human Vaccines and Immunotherapeutics

IS - 3

ER -

Neutralizing antibody response elicited by SARS-CoV-2 receptor-binding domain

Abstract

Keywords

ASJC Scopus subject areas

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