Neutralizing antibody response elicited by SARS-CoV-2 receptor-binding domain

Ping Han Huang; Hsiao Han Tsai; Bo Hung Liao; Yi Ling Lin; Jia Tsrong Jan; Mi Hua Tao; Yu Chi Chou; Che Ming Jack Hu; Hui Wen Chen

doi:10.1080/21645515.2020.1814098

Neutralizing antibody response elicited by SARS-CoV-2 receptor-binding domain

Ping Han Huang
, Hsiao Han Tsai
, Bo Hung Liao
, Yi Ling Lin
, Jia Tsrong Jan
, Mi Hua Tao
, Yu Chi Chou
, Che Ming Jack Hu
, Hui Wen Chen

Research output: Contribution to journal › Comment/debate › peer-review

5 Scopus citations

Abstract

A safe and effective vaccine candidate is urgently needed for the ongoing COVID-19 pandemic, caused by SARS-CoV-2. Here we report that recombinant SARS-CoV-2 RBD protein immunization in mice is able to elicit a strong antibody response and potent neutralizing capability as measured using live or pseudotyped SARS-CoV-2 neutralization assays.

Original language	English (US)
Pages (from-to)	654-655
Number of pages	2
Journal	Human Vaccines and Immunotherapeutics
Volume	17
Issue number	3
DOIs	https://doi.org/10.1080/21645515.2020.1814098
State	Published - 2021
Externally published	Yes

Keywords

SARS-CoV-2
neutralizing antibodies
receptor-binding domain
vaccine

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Pharmacology

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10.1080/21645515.2020.1814098

Cite this

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title = "Neutralizing antibody response elicited by SARS-CoV-2 receptor-binding domain",

abstract = "A safe and effective vaccine candidate is urgently needed for the ongoing COVID-19 pandemic, caused by SARS-CoV-2. Here we report that recombinant SARS-CoV-2 RBD protein immunization in mice is able to elicit a strong antibody response and potent neutralizing capability as measured using live or pseudotyped SARS-CoV-2 neutralization assays.",

keywords = "SARS-CoV-2, neutralizing antibodies, receptor-binding domain, vaccine",

author = "Huang, \{Ping Han\} and Tsai, \{Hsiao Han\} and Liao, \{Bo Hung\} and Lin, \{Yi Ling\} and Jan, \{Jia Tsrong\} and Tao, \{Mi Hua\} and Chou, \{Yu Chi\} and Hu, \{Che Ming Jack\} and Chen, \{Hui Wen\}",

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year = "2021",

doi = "10.1080/21645515.2020.1814098",

language = "English (US)",

volume = "17",

pages = "654--655",

journal = "Human Vaccines and Immunotherapeutics",

issn = "2164-5515",

publisher = "Taylor and Francis Ltd.",

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}

TY - JOUR

T1 - Neutralizing antibody response elicited by SARS-CoV-2 receptor-binding domain

AU - Huang, Ping Han

AU - Tsai, Hsiao Han

AU - Liao, Bo Hung

AU - Lin, Yi Ling

AU - Jan, Jia Tsrong

AU - Tao, Mi Hua

AU - Chou, Yu Chi

AU - Hu, Che Ming Jack

AU - Chen, Hui Wen

PY - 2021

Y1 - 2021

N2 - A safe and effective vaccine candidate is urgently needed for the ongoing COVID-19 pandemic, caused by SARS-CoV-2. Here we report that recombinant SARS-CoV-2 RBD protein immunization in mice is able to elicit a strong antibody response and potent neutralizing capability as measured using live or pseudotyped SARS-CoV-2 neutralization assays.

AB - A safe and effective vaccine candidate is urgently needed for the ongoing COVID-19 pandemic, caused by SARS-CoV-2. Here we report that recombinant SARS-CoV-2 RBD protein immunization in mice is able to elicit a strong antibody response and potent neutralizing capability as measured using live or pseudotyped SARS-CoV-2 neutralization assays.

KW - SARS-CoV-2

KW - neutralizing antibodies

KW - receptor-binding domain

KW - vaccine

UR - https://www.scopus.com/pages/publications/85091731587

UR - https://www.scopus.com/pages/publications/85091731587#tab=citedBy

U2 - 10.1080/21645515.2020.1814098

DO - 10.1080/21645515.2020.1814098

M3 - Comment/debate

C2 - 32991231

AN - SCOPUS:85091731587

SN - 2164-5515

VL - 17

SP - 654

EP - 655

JO - Human Vaccines and Immunotherapeutics

JF - Human Vaccines and Immunotherapeutics

IS - 3

ER -

Neutralizing antibody response elicited by SARS-CoV-2 receptor-binding domain

Abstract

Keywords

ASJC Scopus subject areas

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