Neutropenia is associated with bacteremia in patients infected with the human immunodeficiency virus

Philip Keiser, Elizabeth Higgs, James Smith

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Neutropenia occurs in approximately 17% of symptomatic patients infected with HIV. Results of studies have failed to demonstrate a consistent relationship between HIV-related neutropenia and the subsequent development of bacterial infections. This was a case control study to determine if HIV-related neutropenia was associated with increased rates of bacteremia. The experimental group was comprised of 29 patients infected with HIV that had an absolute neutrophil count less than 1000 cells/mm3 and were paired with 29 control subjects infected with HIV that had been matched for age, sex, CD4 count, and month and year of entry. The frequency of bacteremia was 12.6 per 100 patient months among the experimental group compared to a frequency of 0.87 per 100 patient months among the control group (relative risk [RR] = 14.9, P = 0.0027). Other independent risks for the development of bacteremia included central venous catheters (RR= 3.9, P = 0.03), with a trend toward increased risk for bacteremia in those patients who were intravenous drug users (RR = 3.8, P = 0.11), or who had infiltrative bone marrow disease (RR = 3.1, P = 0.11). Multivariate analysis demonstrated that neutropenia (odds ratio [OR] = 22.6, P = 0.028) and the presence of a central venous catheter (OR = 8.5, P = 0.026) were significant risks for bacteremia. These data suggest that neutropenia is a significant risk for the development of bacteremia in patients infected with HIV.

Original languageEnglish (US)
Pages (from-to)118-122
Number of pages5
JournalAmerican Journal of the Medical Sciences
Volume312
Issue number3
StatePublished - Sep 1996
Externally publishedYes

Fingerprint

Bacteremia
Neutropenia
HIV
Central Venous Catheters
Bone Marrow Diseases
Odds Ratio
CD4 Lymphocyte Count
Drug Users
Bacterial Infections
Case-Control Studies
Neutrophils
Multivariate Analysis
Control Groups

Keywords

  • AIDS
  • bacteremia
  • HIV
  • neutropenia
  • trimethoprim/sulfamethoxazole

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Neutropenia is associated with bacteremia in patients infected with the human immunodeficiency virus. / Keiser, Philip; Higgs, Elizabeth; Smith, James.

In: American Journal of the Medical Sciences, Vol. 312, No. 3, 09.1996, p. 118-122.

Research output: Contribution to journalArticle

@article{61d7b9351374415ba681b9d835c7936b,
title = "Neutropenia is associated with bacteremia in patients infected with the human immunodeficiency virus",
abstract = "Neutropenia occurs in approximately 17{\%} of symptomatic patients infected with HIV. Results of studies have failed to demonstrate a consistent relationship between HIV-related neutropenia and the subsequent development of bacterial infections. This was a case control study to determine if HIV-related neutropenia was associated with increased rates of bacteremia. The experimental group was comprised of 29 patients infected with HIV that had an absolute neutrophil count less than 1000 cells/mm3 and were paired with 29 control subjects infected with HIV that had been matched for age, sex, CD4 count, and month and year of entry. The frequency of bacteremia was 12.6 per 100 patient months among the experimental group compared to a frequency of 0.87 per 100 patient months among the control group (relative risk [RR] = 14.9, P = 0.0027). Other independent risks for the development of bacteremia included central venous catheters (RR= 3.9, P = 0.03), with a trend toward increased risk for bacteremia in those patients who were intravenous drug users (RR = 3.8, P = 0.11), or who had infiltrative bone marrow disease (RR = 3.1, P = 0.11). Multivariate analysis demonstrated that neutropenia (odds ratio [OR] = 22.6, P = 0.028) and the presence of a central venous catheter (OR = 8.5, P = 0.026) were significant risks for bacteremia. These data suggest that neutropenia is a significant risk for the development of bacteremia in patients infected with HIV.",
keywords = "AIDS, bacteremia, HIV, neutropenia, trimethoprim/sulfamethoxazole",
author = "Philip Keiser and Elizabeth Higgs and James Smith",
year = "1996",
month = "9",
language = "English (US)",
volume = "312",
pages = "118--122",
journal = "American Journal of the Medical Sciences",
issn = "0002-9629",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Neutropenia is associated with bacteremia in patients infected with the human immunodeficiency virus

AU - Keiser, Philip

AU - Higgs, Elizabeth

AU - Smith, James

PY - 1996/9

Y1 - 1996/9

N2 - Neutropenia occurs in approximately 17% of symptomatic patients infected with HIV. Results of studies have failed to demonstrate a consistent relationship between HIV-related neutropenia and the subsequent development of bacterial infections. This was a case control study to determine if HIV-related neutropenia was associated with increased rates of bacteremia. The experimental group was comprised of 29 patients infected with HIV that had an absolute neutrophil count less than 1000 cells/mm3 and were paired with 29 control subjects infected with HIV that had been matched for age, sex, CD4 count, and month and year of entry. The frequency of bacteremia was 12.6 per 100 patient months among the experimental group compared to a frequency of 0.87 per 100 patient months among the control group (relative risk [RR] = 14.9, P = 0.0027). Other independent risks for the development of bacteremia included central venous catheters (RR= 3.9, P = 0.03), with a trend toward increased risk for bacteremia in those patients who were intravenous drug users (RR = 3.8, P = 0.11), or who had infiltrative bone marrow disease (RR = 3.1, P = 0.11). Multivariate analysis demonstrated that neutropenia (odds ratio [OR] = 22.6, P = 0.028) and the presence of a central venous catheter (OR = 8.5, P = 0.026) were significant risks for bacteremia. These data suggest that neutropenia is a significant risk for the development of bacteremia in patients infected with HIV.

AB - Neutropenia occurs in approximately 17% of symptomatic patients infected with HIV. Results of studies have failed to demonstrate a consistent relationship between HIV-related neutropenia and the subsequent development of bacterial infections. This was a case control study to determine if HIV-related neutropenia was associated with increased rates of bacteremia. The experimental group was comprised of 29 patients infected with HIV that had an absolute neutrophil count less than 1000 cells/mm3 and were paired with 29 control subjects infected with HIV that had been matched for age, sex, CD4 count, and month and year of entry. The frequency of bacteremia was 12.6 per 100 patient months among the experimental group compared to a frequency of 0.87 per 100 patient months among the control group (relative risk [RR] = 14.9, P = 0.0027). Other independent risks for the development of bacteremia included central venous catheters (RR= 3.9, P = 0.03), with a trend toward increased risk for bacteremia in those patients who were intravenous drug users (RR = 3.8, P = 0.11), or who had infiltrative bone marrow disease (RR = 3.1, P = 0.11). Multivariate analysis demonstrated that neutropenia (odds ratio [OR] = 22.6, P = 0.028) and the presence of a central venous catheter (OR = 8.5, P = 0.026) were significant risks for bacteremia. These data suggest that neutropenia is a significant risk for the development of bacteremia in patients infected with HIV.

KW - AIDS

KW - bacteremia

KW - HIV

KW - neutropenia

KW - trimethoprim/sulfamethoxazole

UR - http://www.scopus.com/inward/record.url?scp=0029824660&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029824660&partnerID=8YFLogxK

M3 - Article

VL - 312

SP - 118

EP - 122

JO - American Journal of the Medical Sciences

JF - American Journal of the Medical Sciences

SN - 0002-9629

IS - 3

ER -