New developments in the management of preterm labor

Radek Bukowski, George Saade

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Current management of preterm labor has not changed the incidence of preterm delivery; therefore, significant research effort has been concentrated on the search for new methods of management. New tocolytics like inhibitors of cyclooxygenase 2 and nitric oxide donors have been tested in animal models and in preliminary clinical trials with promising results. Inhibition of cervical ripening may be one alternative to tocolysis. This new approach has a potential to be a valuable method of management of preterm labor if human studies confirm the promising results reported in animals. Growing evidence suggests that premature delivery may be associated with infection or fetal growth abnormalities, with dire consequences to the fetus. If these associations are to be included in risk and benefit assessment, then inhibition of preterm labor may prove to be detrimental to the fetus.

Original languageEnglish (US)
Pages (from-to)272-294
Number of pages23
JournalSeminars in Perinatology
Volume25
Issue number5
StatePublished - 2001

Fingerprint

Premature Obstetric Labor
Fetus
Cervical Ripening
Tocolytic Agents
Tocolysis
Nitric Oxide Donors
Cyclooxygenase 2 Inhibitors
Fetal Development
Animal Models
Clinical Trials
Incidence
Infection
Research

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

New developments in the management of preterm labor. / Bukowski, Radek; Saade, George.

In: Seminars in Perinatology, Vol. 25, No. 5, 2001, p. 272-294.

Research output: Contribution to journalArticle

Bukowski, Radek ; Saade, George. / New developments in the management of preterm labor. In: Seminars in Perinatology. 2001 ; Vol. 25, No. 5. pp. 272-294.
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