New insights into flavivirus evolution, taxonomy and biogeographic history, extended by analysis of canonical and alternative coding sequences e0117849

Gregory Moureau, Shelley Cook, Philippe Lemey, Antoine Nougairede, Naomi L. Forrester, Maxim Khasnatinov, Remi N. Charrel, Andrew E. Firth, Ernest A. Gould, Xavier De Lamballerie

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

To generate the most diverse phylogenetic dataset for the flaviviruses to date, we determined the genomic sequences and phylogenetic relationships of 14 flaviviruses, of which 10 are primarily associated with Culex spp. mosquitoes. We analyze these data, in conjunction with a comprehensive collection of flavivirus genomes, to characterize flavivirus evolutionary and biogeographic history in unprecedented detail and breadth. Based on the presumed introduction of yellow fever virus into the Americas via the transatlantic slave trade, we extrapolated a timescale for a relevant subset of flaviviruses whose evolutionary history, shows that different Culex-spp. associated flaviviruses have been introduced from the Old World to the New World on at least five separate occasions, with 2 different sets of factors likely to have contributed to the dispersal of the different viruses. We also discuss the significance of programmed ribosomal frameshifting in a central region of the polyprotein open reading frame in some mosquito-associated flaviviruses.

Original languageEnglish (US)
Article numbere0117849
JournalPLoS One
Volume10
Issue number2
DOIs
StatePublished - Feb 26 2015

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Flaviviridae
Flavivirus
Taxonomies
Viruses
History
taxonomy
Polyproteins
history
Culex
Genes
Culicidae
Yellow fever virus
phylogeny
Ribosomal Frameshifting
Slaves
open reading frames
genomics
Open Reading Frames
viruses
genome

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Moureau, G., Cook, S., Lemey, P., Nougairede, A., Forrester, N. L., Khasnatinov, M., ... De Lamballerie, X. (2015). New insights into flavivirus evolution, taxonomy and biogeographic history, extended by analysis of canonical and alternative coding sequences e0117849. PLoS One, 10(2), [e0117849]. https://doi.org/10.1371/journal.pone.0117849

New insights into flavivirus evolution, taxonomy and biogeographic history, extended by analysis of canonical and alternative coding sequences e0117849. / Moureau, Gregory; Cook, Shelley; Lemey, Philippe; Nougairede, Antoine; Forrester, Naomi L.; Khasnatinov, Maxim; Charrel, Remi N.; Firth, Andrew E.; Gould, Ernest A.; De Lamballerie, Xavier.

In: PLoS One, Vol. 10, No. 2, e0117849, 26.02.2015.

Research output: Contribution to journalArticle

Moureau, G, Cook, S, Lemey, P, Nougairede, A, Forrester, NL, Khasnatinov, M, Charrel, RN, Firth, AE, Gould, EA & De Lamballerie, X 2015, 'New insights into flavivirus evolution, taxonomy and biogeographic history, extended by analysis of canonical and alternative coding sequences e0117849', PLoS One, vol. 10, no. 2, e0117849. https://doi.org/10.1371/journal.pone.0117849
Moureau, Gregory ; Cook, Shelley ; Lemey, Philippe ; Nougairede, Antoine ; Forrester, Naomi L. ; Khasnatinov, Maxim ; Charrel, Remi N. ; Firth, Andrew E. ; Gould, Ernest A. ; De Lamballerie, Xavier. / New insights into flavivirus evolution, taxonomy and biogeographic history, extended by analysis of canonical and alternative coding sequences e0117849. In: PLoS One. 2015 ; Vol. 10, No. 2.
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