New Insights into the Function of IAP Proteins: Modulation of the MYC/MAX/MAD Network

Casey W. Wright, Colin S. Duckett

Research output: Contribution to journalShort surveypeer-review

3 Scopus citations

Abstract

A growing number of studies have revealed that the inhibitor of apoptosis (IAP) proteins play a variety of cellular roles in addition to suppression of apoptosis. A recent study in Molecular Cell demonstrates that one IAP member, c-IAP1, functions to potentiate the activity of Myc by triggering the ubiquitination and proteasomal degradation of the Myc inhibitory protein Mad1.

Original languageEnglish (US)
Pages (from-to)3-4
Number of pages2
JournalDevelopmental cell
Volume14
Issue number1
DOIs
StatePublished - Jan 15 2008

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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