New Insights into the Function of IAP Proteins: Modulation of the MYC/MAX/MAD Network

Casey Wright, Colin S. Duckett

Research output: Contribution to journalShort survey

3 Scopus citations


A growing number of studies have revealed that the inhibitor of apoptosis (IAP) proteins play a variety of cellular roles in addition to suppression of apoptosis. A recent study in Molecular Cell demonstrates that one IAP member, c-IAP1, functions to potentiate the activity of Myc by triggering the ubiquitination and proteasomal degradation of the Myc inhibitory protein Mad1.

Original languageEnglish (US)
Pages (from-to)3-4
Number of pages2
JournalDevelopmental Cell
Issue number1
StatePublished - Jan 15 2008
Externally publishedYes


ASJC Scopus subject areas

  • Developmental Biology

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