New Insights into the Pathogenesis and Treatment of Malnutrition

Grace E. Thaxton, Peter Melby, Mark J. Manary, Geoffrey A. Preidis

Research output: Contribution to journalArticle

Abstract

The volume of research into the pathogenesis and treatment of malnutrition has increased markedly over the past ten years, providing mechanistic insights that can be leveraged into more effective treatment options. These discoveries have been driven by several landmark studies employing metabolomics, metagenomics, and new preclinical models. This review highlights some of the most important recent findings, focusing in particular on the emerging roles of prenatal and perinatal factors, protein deficiency, impaired gut barrier function, immune deficiency, and the intestinal microbiome.

Original languageEnglish (US)
JournalGastroenterology Clinics of North America
DOIs
StateAccepted/In press - Jan 1 2018

    Fingerprint

Keywords

  • Epigenetics
  • Immune deficiency
  • Intestinal microbiota
  • Perinatal
  • Prenatal
  • Protein deficiency
  • Therapeutic foods
  • Undernutrition

ASJC Scopus subject areas

  • Gastroenterology

Cite this