New Insights into the Pathogenesis and Treatment of Malnutrition

Grace E. Thaxton, Peter Melby, Mark J. Manary, Geoffrey A. Preidis

Research output: Contribution to journalArticle

Abstract

The volume of research into the pathogenesis and treatment of malnutrition has increased markedly over the past ten years, providing mechanistic insights that can be leveraged into more effective treatment options. These discoveries have been driven by several landmark studies employing metabolomics, metagenomics, and new preclinical models. This review highlights some of the most important recent findings, focusing in particular on the emerging roles of prenatal and perinatal factors, protein deficiency, impaired gut barrier function, immune deficiency, and the intestinal microbiome.

Original languageEnglish (US)
JournalGastroenterology Clinics of North America
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Metagenomics
Protein Deficiency
Metabolomics
Malnutrition
Research
Gastrointestinal Microbiome

Keywords

  • Epigenetics
  • Immune deficiency
  • Intestinal microbiota
  • Perinatal
  • Prenatal
  • Protein deficiency
  • Therapeutic foods
  • Undernutrition

ASJC Scopus subject areas

  • Gastroenterology

Cite this

New Insights into the Pathogenesis and Treatment of Malnutrition. / Thaxton, Grace E.; Melby, Peter; Manary, Mark J.; Preidis, Geoffrey A.

In: Gastroenterology Clinics of North America, 01.01.2018.

Research output: Contribution to journalArticle

@article{058faed0881345febe3a472a679dbb8b,
title = "New Insights into the Pathogenesis and Treatment of Malnutrition",
abstract = "The volume of research into the pathogenesis and treatment of malnutrition has increased markedly over the past ten years, providing mechanistic insights that can be leveraged into more effective treatment options. These discoveries have been driven by several landmark studies employing metabolomics, metagenomics, and new preclinical models. This review highlights some of the most important recent findings, focusing in particular on the emerging roles of prenatal and perinatal factors, protein deficiency, impaired gut barrier function, immune deficiency, and the intestinal microbiome.",
keywords = "Epigenetics, Immune deficiency, Intestinal microbiota, Perinatal, Prenatal, Protein deficiency, Therapeutic foods, Undernutrition",
author = "Thaxton, {Grace E.} and Peter Melby and Manary, {Mark J.} and Preidis, {Geoffrey A.}",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.gtc.2018.07.007",
language = "English (US)",
journal = "Gastroenterology Clinics of North America",
issn = "0889-8553",
publisher = "W.B. Saunders Ltd",

}

TY - JOUR

T1 - New Insights into the Pathogenesis and Treatment of Malnutrition

AU - Thaxton, Grace E.

AU - Melby, Peter

AU - Manary, Mark J.

AU - Preidis, Geoffrey A.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - The volume of research into the pathogenesis and treatment of malnutrition has increased markedly over the past ten years, providing mechanistic insights that can be leveraged into more effective treatment options. These discoveries have been driven by several landmark studies employing metabolomics, metagenomics, and new preclinical models. This review highlights some of the most important recent findings, focusing in particular on the emerging roles of prenatal and perinatal factors, protein deficiency, impaired gut barrier function, immune deficiency, and the intestinal microbiome.

AB - The volume of research into the pathogenesis and treatment of malnutrition has increased markedly over the past ten years, providing mechanistic insights that can be leveraged into more effective treatment options. These discoveries have been driven by several landmark studies employing metabolomics, metagenomics, and new preclinical models. This review highlights some of the most important recent findings, focusing in particular on the emerging roles of prenatal and perinatal factors, protein deficiency, impaired gut barrier function, immune deficiency, and the intestinal microbiome.

KW - Epigenetics

KW - Immune deficiency

KW - Intestinal microbiota

KW - Perinatal

KW - Prenatal

KW - Protein deficiency

KW - Therapeutic foods

KW - Undernutrition

UR - http://www.scopus.com/inward/record.url?scp=85054006714&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054006714&partnerID=8YFLogxK

U2 - 10.1016/j.gtc.2018.07.007

DO - 10.1016/j.gtc.2018.07.007

M3 - Article

JO - Gastroenterology Clinics of North America

JF - Gastroenterology Clinics of North America

SN - 0889-8553

ER -