New metrics for evaluating viral respiratory pathogenesis

Vineet Menachery, Lisa E. Gralinski, Ralph S. Baric, Martin T. Ferris

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Viral pathogenesis studies in mice have relied on markers of severe systemic disease, rather than clinically relevant measures, to evaluate respiratory virus infection; thus confounding connections to human disease. Here, whole-body plethysmography was used to directly measure changes in pulmonary function during two respiratory viral infections. This methodology closely tracked with traditional pathogenesis metrics, distinguished both virus- and dose-specific responses, and identified long-term respiratory changes following both SARS-CoV and Influenza A Virus infection. Together, the work highlights the utility of examining respiratory function following infection in order to fully understand viral pathogenesis.

Original languageEnglish (US)
Article numbere0131451
JournalPLoS One
Volume10
Issue number6
DOIs
StatePublished - Jun 26 2015
Externally publishedYes

Fingerprint

Virus Diseases
Viruses
pathogenesis
Respiratory Tract Infections
lung function
Whole Body Plethysmography
Plethysmography
SARS Virus
infection
Influenza A virus
viruses
human diseases
Lung
Infection
mice
dosage
methodology

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

New metrics for evaluating viral respiratory pathogenesis. / Menachery, Vineet; Gralinski, Lisa E.; Baric, Ralph S.; Ferris, Martin T.

In: PLoS One, Vol. 10, No. 6, e0131451, 26.06.2015.

Research output: Contribution to journalArticle

Menachery, Vineet ; Gralinski, Lisa E. ; Baric, Ralph S. ; Ferris, Martin T. / New metrics for evaluating viral respiratory pathogenesis. In: PLoS One. 2015 ; Vol. 10, No. 6.
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