New strategies for effective treatment of vitamin K antagonist-associated bleeding

Sean Yates, R. Sarode

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Vitamin K antagonists have been used as oral anticoagulants in the treatment and prevention of thromboembolic events for over half a century. Although vitamin K antagonists are effective in the management of thromboembolic events, the need for routine monitoring and the associated risk of bleeding has resulted in the development and licensing of direct oral anticoagulants for specific clinical indications. Despite these developments, vitamin K antagonists remain the oral anticoagulants of choice in many clinical conditions. Severe bleeding associated with oral anticoagulation requires urgent reversal. Several options for the reversal of vitamin K antagonist exist, including vitamin K, prothrombin complex concentrates and plasma. In this manuscript, we review current evidence and provide physicians with treatment strategies for more effective management of vitamin K antagonist-associated bleeding.

Original languageEnglish (US)
Pages (from-to)S180-S186
JournalJournal of Thrombosis and Haemostasis
Volume13
Issue numberS1
DOIs
StatePublished - Jun 1 2015
Externally publishedYes

Fingerprint

Vitamin K
Hemorrhage
Anticoagulants
Therapeutics
Licensure
Physicians

Keywords

  • Coumarins
  • Plasma
  • Prothrombin complex concentrates
  • Vitamin K
  • Warfarin

ASJC Scopus subject areas

  • Hematology
  • Medicine(all)

Cite this

New strategies for effective treatment of vitamin K antagonist-associated bleeding. / Yates, Sean; Sarode, R.

In: Journal of Thrombosis and Haemostasis, Vol. 13, No. S1, 01.06.2015, p. S180-S186.

Research output: Contribution to journalReview article

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