Newly discovered Ebola virus associated with hemorrhagic fever outbreak in Uganda

Jonathan S. Towner; Tara K. Sealy; Marina L. Khristova; César G. Albariño; Sean Conlan; Serena A. Reeder; Phenix Lan Quan; W. Ian Lipkin; Robert Downing; Jordan W. Tappero; Samuel Okware; Julius Lutwama; Barnabas Bakamutumaho; John Kayiwa; James A. Comer; Pierre E. Rollin; Thomas G. Ksiazek; Stuart T. Nichol

doi:10.1371/journal.ppat.1000212

Newly discovered Ebola virus associated with hemorrhagic fever outbreak in Uganda

Jonathan S. Towner, Tara K. Sealy, Marina L. Khristova, César G. Albariño, Sean Conlan, Serena A. Reeder, Phenix Lan Quan, W. Ian Lipkin, Robert Downing, Jordan W. Tappero, Samuel Okware, Julius Lutwama, Barnabas Bakamutumaho, John Kayiwa, James A. Comer, Pierre E. Rollin, Thomas G. Ksiazek, Stuart T. Nichol

Research output: Contribution to journal › Article › peer-review

424 Scopus citations

Abstract

Over the past 30 years, Zaire and Sudan ebolaviruses have been responsible for large hemorrhagic fever (HF) outbreaks with case fatalities ranging from 53% to 90%, while a third species, Côte d'Ivoire ebolavirus, caused a single non-fatal HF case. In November 2007, HF cases were reported in Bundibugyo District, Western Uganda. Laboratory investigation of the initial 29 suspect-case blood specimens by classic methods (antigen capture, IgM and IgG ELISA) and a recently developed randomprimed pyrosequencing approach quickly identified this to be an Ebola HF outbreak associated with a newly discovered ebolavirus species (Bundibugyo ebolavirus) distantly related to the Côte d'Ivoire ebolavirus found in western Africa. Due to the sequence divergence of this new virus relative to all previously recognized ebolaviruses, these findings have important implications for design of future diagnostic assays to monitor Ebola HF disease in humans and animals, and ongoing efforts to develop effective antivirals and vaccines.

Original language	English (US)
Article number	e1000212
Journal	PLoS pathogens
Volume	4
Issue number	11
DOIs	https://doi.org/10.1371/journal.ppat.1000212
State	Published - Nov 2008
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Molecular Biology
Genetics
Virology

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10.1371/journal.ppat.1000212

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Towner, J. S., Sealy, T. K., Khristova, M. L., Albariño, C. G., Conlan, S., Reeder, S. A., Quan, P. L., Lipkin, W. I., Downing, R., Tappero, J. W., Okware, S., Lutwama, J., Bakamutumaho, B., Kayiwa, J., Comer, J. A., Rollin, P. E., Ksiazek, T. G., & Nichol, S. T. (2008). Newly discovered Ebola virus associated with hemorrhagic fever outbreak in Uganda. PLoS pathogens, 4(11), Article e1000212. https://doi.org/10.1371/journal.ppat.1000212

Towner, JS, Sealy, TK, Khristova, ML, Albariño, CG, Conlan, S, Reeder, SA, Quan, PL, Lipkin, WI, Downing, R, Tappero, JW, Okware, S, Lutwama, J, Bakamutumaho, B, Kayiwa, J, Comer, JA, Rollin, PE, Ksiazek, TG & Nichol, ST 2008, 'Newly discovered Ebola virus associated with hemorrhagic fever outbreak in Uganda', PLoS pathogens, vol. 4, no. 11, e1000212. https://doi.org/10.1371/journal.ppat.1000212

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Newly discovered Ebola virus associated with hemorrhagic fever outbreak in Uganda

Abstract

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