Newly discovered Ebola virus associated with hemorrhagic fever outbreak in Uganda

Jonathan S. Towner, Tara K. Sealy, Marina L. Khristova, César G. Albariño, Sean Conlan, Serena A. Reeder, Phenix Lan Quan, W. Ian Lipkin, Robert Downing, Jordan W. Tappero, Samuel Okware, Julius Lutwama, Barnabas Bakamutumaho, John Kayiwa, James A. Comer, Pierre E. Rollin, Thomas Ksiazek, Stuart T. Nichol

Research output: Contribution to journalArticle

329 Citations (Scopus)

Abstract

Over the past 30 years, Zaire and Sudan ebolaviruses have been responsible for large hemorrhagic fever (HF) outbreaks with case fatalities ranging from 53% to 90%, while a third species, Côte d'Ivoire ebolavirus, caused a single non-fatal HF case. In November 2007, HF cases were reported in Bundibugyo District, Western Uganda. Laboratory investigation of the initial 29 suspect-case blood specimens by classic methods (antigen capture, IgM and IgG ELISA) and a recently developed randomprimed pyrosequencing approach quickly identified this to be an Ebola HF outbreak associated with a newly discovered ebolavirus species (Bundibugyo ebolavirus) distantly related to the Côte d'Ivoire ebolavirus found in western Africa. Due to the sequence divergence of this new virus relative to all previously recognized ebolaviruses, these findings have important implications for design of future diagnostic assays to monitor Ebola HF disease in humans and animals, and ongoing efforts to develop effective antivirals and vaccines.

Original languageEnglish (US)
Article numbere1000212
JournalPLoS Pathogens
Volume4
Issue number11
DOIs
StatePublished - Nov 2008
Externally publishedYes

Fingerprint

Ebolavirus
Uganda
Disease Outbreaks
Fever
Ebola Hemorrhagic Fever
Democratic Republic of the Congo
Sudan
Western Africa
Antiviral Agents
Immunoglobulin M
Vaccines
Immunoglobulin G
Enzyme-Linked Immunosorbent Assay
Viruses
Antigens

ASJC Scopus subject areas

  • Microbiology
  • Parasitology
  • Virology
  • Immunology
  • Genetics
  • Molecular Biology

Cite this

Towner, J. S., Sealy, T. K., Khristova, M. L., Albariño, C. G., Conlan, S., Reeder, S. A., ... Nichol, S. T. (2008). Newly discovered Ebola virus associated with hemorrhagic fever outbreak in Uganda. PLoS Pathogens, 4(11), [e1000212]. https://doi.org/10.1371/journal.ppat.1000212

Newly discovered Ebola virus associated with hemorrhagic fever outbreak in Uganda. / Towner, Jonathan S.; Sealy, Tara K.; Khristova, Marina L.; Albariño, César G.; Conlan, Sean; Reeder, Serena A.; Quan, Phenix Lan; Lipkin, W. Ian; Downing, Robert; Tappero, Jordan W.; Okware, Samuel; Lutwama, Julius; Bakamutumaho, Barnabas; Kayiwa, John; Comer, James A.; Rollin, Pierre E.; Ksiazek, Thomas; Nichol, Stuart T.

In: PLoS Pathogens, Vol. 4, No. 11, e1000212, 11.2008.

Research output: Contribution to journalArticle

Towner, JS, Sealy, TK, Khristova, ML, Albariño, CG, Conlan, S, Reeder, SA, Quan, PL, Lipkin, WI, Downing, R, Tappero, JW, Okware, S, Lutwama, J, Bakamutumaho, B, Kayiwa, J, Comer, JA, Rollin, PE, Ksiazek, T & Nichol, ST 2008, 'Newly discovered Ebola virus associated with hemorrhagic fever outbreak in Uganda', PLoS Pathogens, vol. 4, no. 11, e1000212. https://doi.org/10.1371/journal.ppat.1000212
Towner JS, Sealy TK, Khristova ML, Albariño CG, Conlan S, Reeder SA et al. Newly discovered Ebola virus associated with hemorrhagic fever outbreak in Uganda. PLoS Pathogens. 2008 Nov;4(11). e1000212. https://doi.org/10.1371/journal.ppat.1000212
Towner, Jonathan S. ; Sealy, Tara K. ; Khristova, Marina L. ; Albariño, César G. ; Conlan, Sean ; Reeder, Serena A. ; Quan, Phenix Lan ; Lipkin, W. Ian ; Downing, Robert ; Tappero, Jordan W. ; Okware, Samuel ; Lutwama, Julius ; Bakamutumaho, Barnabas ; Kayiwa, John ; Comer, James A. ; Rollin, Pierre E. ; Ksiazek, Thomas ; Nichol, Stuart T. / Newly discovered Ebola virus associated with hemorrhagic fever outbreak in Uganda. In: PLoS Pathogens. 2008 ; Vol. 4, No. 11.
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