@article{d21ac6700df24d7ca415a1265a9a746f,
title = "Newly synthesized 3-sulfenylindole derivatives from 4-hydroxydithiocoumarin using an oxidative cross dehydrogenative coupling reaction (OCDCR): potential lead molecules for antiproliferative activity",
abstract = "An expedient and efficient synthetic method was developed for the oxidative cross dehydrogenative coupling reaction between 4-hydroxydithiocoumarin and indole at the C-3 position regio-selectively using a combination of 10 mol% molecular iodine and TBHP in the presence of 10 mol% CuBr2as an additive at room temperature. Mild reaction conditions, good yields and a broad substrate scope are some of the salient features of the present protocol. Additionally, the synthesized 3-sulfenylindoles derived from 4-hydroxydithiocoumarin were converted into biologically active sulfone derivatives. Interestingly, some of the compounds exhibit anti-cell proliferative activity on breast cancer (MCF-7) cells due to reactive oxygen species (ROS) mediated cell damage.",
author = "Santa Mondal and Karuna Mahato and Neha Arora and Dheerendra Kankane and Singh, {Umed Pratap} and Saghir Ali and Khan, {Aftab Hossain} and Ghosh, {Siddhartha S.} and Khan, {Abu T.}",
note = "Funding Information: Santa Mondal and Saghir Ali are thankful to IIT Guwahati for providing their research fellowships. We are grateful to the Department of Science and Technology, New Delhi for financial support to A. T. K. as research Grant No. CRG/2018/002120/OC. The authors are thankful to the MHRD for the 400 MHz NMR facility (Grant No. F. No. 5-5/2014-TS-VII). We are also thankful to CIF IIT Guwahati for their instrumentation facility (600 MHz NMR, XRD). We also acknowledge the support of the DBT programme support project facility for the cell culture based experiments. We are extremely thankful to all the referees for their valuable comments and suggestions on our manuscript. We are highly grateful to the editor for his valuable suggestions. Funding Information: Santa Mondal and Saghir Ali are thankful to IIT Guwahati for providing their research fellowships. We are grateful to the Department of Science and Technology, New Delhi for financial support to A. T. K. as research Grant No. CRG/2018/ 002120/OC. The authors are thankful to the MHRD for the 400 MHz NMR facility (Grant No. F. No. 5-5/2014-TS-VII). We are also thankful to CIF IIT Guwahati for their instrumentation facility (600 MHz NMR, XRD). Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2020.",
year = "2020",
month = jun,
day = "7",
doi = "10.1039/d0ob00054j",
language = "English (US)",
volume = "18",
pages = "4104--4113",
journal = "Organic and Biomolecular Chemistry",
issn = "1477-0520",
publisher = "Royal Society of Chemistry",
number = "21",
}