Next-generation CAR T cell therapies for glioblastoma

Joshua D. Bernstock; Jakob V.E. Gerstl; Pablo A. Valdés; Gregory K. Friedman; E. Antonio Chiocca

doi:10.1126/scitranslmed.adp2660

Next-generation CAR T cell therapies for glioblastoma

Joshua D. Bernstock, Jakob V.E. Gerstl, Pablo A. Valdés, Gregory K. Friedman, E. Antonio Chiocca

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Interim results from two phase 1 trials demonstrate progress in the use of chimeric antigen receptor (CAR) T cell therapy for recurrent glioblastoma (GBM).

Original language	English (US)
Article number	eadp2660
Pages (from-to)	eadp2660
Journal	Science Translational Medicine
Volume	16
Issue number	762
DOIs	https://doi.org/10.1126/scitranslmed.adp2660
State	Published - Aug 28 2024
Externally published	Yes

Keywords

Glioblastoma/therapy
T-Lymphocytes/immunology
Immunotherapy, Adoptive/methods
Humans
Brain Neoplasms/therapy
Receptors, Chimeric Antigen/immunology
Receptors, Antigen, T-Cell/metabolism

ASJC Scopus subject areas

General Medicine

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10.1126/scitranslmed.adp2660

Cite this

@article{76322da29e864c15ae6275e3f0c9a3aa,

title = "Next-generation CAR T cell therapies for glioblastoma",

abstract = "Interim results from two phase 1 trials demonstrate progress in the use of chimeric antigen receptor (CAR) T cell therapy for recurrent glioblastoma (GBM).",

keywords = "Glioblastoma/therapy, T-Lymphocytes/immunology, Immunotherapy, Adoptive/methods, Humans, Brain Neoplasms/therapy, Receptors, Chimeric Antigen/immunology, Receptors, Antigen, T-Cell/metabolism",

author = "Bernstock, {Joshua D.} and Gerstl, {Jakob V.E.} and Vald{\'e}s, {Pablo A.} and Friedman, {Gregory K.} and Chiocca, {E. Antonio}",

year = "2024",

month = aug,

day = "28",

doi = "10.1126/scitranslmed.adp2660",

language = "English (US)",

volume = "16",

pages = "eadp2660",

journal = "Science Translational Medicine",

issn = "1946-6234",

publisher = "American Association for the Advancement of Science",

number = "762",

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TY - JOUR

T1 - Next-generation CAR T cell therapies for glioblastoma

AU - Bernstock, Joshua D.

AU - Gerstl, Jakob V.E.

AU - Valdés, Pablo A.

AU - Friedman, Gregory K.

AU - Chiocca, E. Antonio

PY - 2024/8/28

Y1 - 2024/8/28

N2 - Interim results from two phase 1 trials demonstrate progress in the use of chimeric antigen receptor (CAR) T cell therapy for recurrent glioblastoma (GBM).

AB - Interim results from two phase 1 trials demonstrate progress in the use of chimeric antigen receptor (CAR) T cell therapy for recurrent glioblastoma (GBM).

KW - Glioblastoma/therapy

KW - T-Lymphocytes/immunology

KW - Immunotherapy, Adoptive/methods

KW - Humans

KW - Brain Neoplasms/therapy

KW - Receptors, Chimeric Antigen/immunology

KW - Receptors, Antigen, T-Cell/metabolism

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U2 - 10.1126/scitranslmed.adp2660

DO - 10.1126/scitranslmed.adp2660

M3 - Review article

C2 - 39196960

AN - SCOPUS:85202729235

SN - 1946-6234

VL - 16

SP - eadp2660

JO - Science Translational Medicine

JF - Science Translational Medicine

IS - 762

M1 - eadp2660

ER -

Next-generation CAR T cell therapies for glioblastoma

Abstract

Keywords

ASJC Scopus subject areas

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Hyperspectral, Quantitative Intraoperative Fluorescence Image Guided Brain Surgery

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Next-generation CAR T cell therapies for glioblastoma

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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Hyperspectral, Quantitative Intraoperative Fluorescence Image Guided Brain Surgery

Cite this