NF-κB activity decreases in basal forebrain of young and aged rats after hyperoxia

Tracy Toliver-Kinsky, David Rassin, J. Regino Perez-Polo

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Hyperoxia is an oxidative stressor that triggers signaling cascades via changes in promoter activation by transcription factors. The transcription factor NF-κB has been shown to regulate transcription of many genes that play a role in inflammation and recovery from acute or chronic trauma. Here we describe the effects of hyperoxia on basal levels of NF-κB activity in young and aged rat forebrain. The results would suggest that chronic stress may have different effects on NF-κB basal activity levels as compared to the effects of an acute stress such as hyperoxia and that there is a diminished response to hyperoxia in the aged basal forebrain.

Original languageEnglish (US)
Pages (from-to)899-905
Number of pages7
JournalNeurobiology of aging
Issue number5
StatePublished - Sep 2002


  • Aged
  • Basal forebrain
  • Hyperoxia
  • NF-κB
  • Oxidative stress

ASJC Scopus subject areas

  • General Neuroscience
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology


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