NF-κB activity decreases in basal forebrain of young and aged rats after hyperoxia

Tracy Toliver-Kinsky, David Rassin, J. Regino Perez-Polo

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Hyperoxia is an oxidative stressor that triggers signaling cascades via changes in promoter activation by transcription factors. The transcription factor NF-κB has been shown to regulate transcription of many genes that play a role in inflammation and recovery from acute or chronic trauma. Here we describe the effects of hyperoxia on basal levels of NF-κB activity in young and aged rat forebrain. The results would suggest that chronic stress may have different effects on NF-κB basal activity levels as compared to the effects of an acute stress such as hyperoxia and that there is a diminished response to hyperoxia in the aged basal forebrain.

Original languageEnglish (US)
Pages (from-to)899-905
Number of pages7
JournalNeurobiology of Aging
Volume23
Issue number5
DOIs
StatePublished - Sep 2002

Fingerprint

Hyperoxia
Transcription Factors
Prosencephalon
Inflammation
Basal Forebrain
Wounds and Injuries
Genes

Keywords

  • Aged
  • Basal forebrain
  • Hyperoxia
  • NF-κB
  • Oxidative stress

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

NF-κB activity decreases in basal forebrain of young and aged rats after hyperoxia. / Toliver-Kinsky, Tracy; Rassin, David; Perez-Polo, J. Regino.

In: Neurobiology of Aging, Vol. 23, No. 5, 09.2002, p. 899-905.

Research output: Contribution to journalArticle

Toliver-Kinsky, Tracy ; Rassin, David ; Perez-Polo, J. Regino. / NF-κB activity decreases in basal forebrain of young and aged rats after hyperoxia. In: Neurobiology of Aging. 2002 ; Vol. 23, No. 5. pp. 899-905.
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