Ngari virus is a Bunyamwera virus reassortant that can be associated with large outbreaks of hemorrhagic fever in Africa

Sonja R. Gerrard, Li Li, Alan Barrett, Stuart T. Nichol

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Two isolates of a virus of the genus Orthobunyavirus (family Bunyaviridae) were obtained from hemorrhagic fever cases during a large disease outbreak in East Africa in 1997 and 1998. Sequence analysis of regions of the three genomic RNA segments of the virus (provisionally referred to as Garissa virus) suggested that it was a genetic reassortant virus with S and L segments derived from Bunyamwera virus but an M segment from an unidentified virus of the genus Orthobunyavirus. While high genetic diversity (52%) was revealed by analysis of virus M segment nucleotide sequences obtained from 21 members of the genus Orthobunyavirus, the Garissa and Ngari virus M segments were almost identical. Surprisingly, the Ngari virus L and S segments showed high sequence identity with those of Bunyamwera virus, showing that Garissa virus is an isolate of Ngari virus, which in turn is a Bunyamwera virus reassortant. Ngari virus should be considered when investigating hemorrhagic fever outbreaks throughout sub-Saharan Africa.

Original languageEnglish (US)
Pages (from-to)8922-8926
Number of pages5
JournalJournal of Virology
Volume78
Issue number16
DOIs
StatePublished - Aug 2004

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Bunyamwera virus
fever
Disease Outbreaks
Fever
Viruses
Orthobunyavirus
viruses
Bunyaviridae
Reassortant Viruses
Sub-Saharan Africa
Eastern Africa
Africa South of the Sahara
RNA Viruses
sequence analysis
RNA
Sequence Analysis
genomics
nucleotide sequences
genetic variation

ASJC Scopus subject areas

  • Immunology

Cite this

Ngari virus is a Bunyamwera virus reassortant that can be associated with large outbreaks of hemorrhagic fever in Africa. / Gerrard, Sonja R.; Li, Li; Barrett, Alan; Nichol, Stuart T.

In: Journal of Virology, Vol. 78, No. 16, 08.2004, p. 8922-8926.

Research output: Contribution to journalArticle

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