NGF levels decrease in the spinal cord and dorsal root ganglion after spinal hemisection

Adrianne D. Bennett, Giulio Taglialatela, Regino Perez-Polo, Claire E. Hulsebosch

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

To examine changes in nerve growth factor (NGF) levels in spinal cord and dorsal root ganglia (DRG) after spinal injury, male Sprague-Dawley rats weighing 150-175 g were given spinal hemisections. NGF content was measured at various post-surgical times and compared with naive controls (n=4 per time point) in the spinal cord, DRG and blood serum by ELISA techniques (Promega). Levels of NGF in the blood serum were significantly increased 8-fold at 48 h but were significantly decreased in the spinal cord and DRG by 2- to 4-fold until 7 days postsurgery (ANOVA, p<0.05). Contrary to accepted dogma, spinal injury results in decreased levels of NGF in the spinal cord and DRG following spinal injury.

Original languageEnglish (US)
Pages (from-to)889-893
Number of pages5
JournalNeuroReport
Volume10
Issue number4
DOIs
StatePublished - Mar 17 1999

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Keywords

  • Dorsal root ganglia
  • NGF
  • Nerve growth factor
  • Neurotrophin
  • Neurotropin
  • Rat, Spinal cord injury

ASJC Scopus subject areas

  • Neuroscience(all)

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