NGF levels decrease in the spinal cord and dorsal root ganglion after spinal hemisection

Adrianne D. Bennett, Giulio Taglialatela, Regino Perez-Polo, Claire E. Hulsebosch

    Research output: Contribution to journalArticlepeer-review

    22 Scopus citations

    Abstract

    To examine changes in nerve growth factor (NGF) levels in spinal cord and dorsal root ganglia (DRG) after spinal injury, male Sprague-Dawley rats weighing 150-175 g were given spinal hemisections. NGF content was measured at various post-surgical times and compared with naive controls (n=4 per time point) in the spinal cord, DRG and blood serum by ELISA techniques (Promega). Levels of NGF in the blood serum were significantly increased 8-fold at 48 h but were significantly decreased in the spinal cord and DRG by 2- to 4-fold until 7 days postsurgery (ANOVA, p<0.05). Contrary to accepted dogma, spinal injury results in decreased levels of NGF in the spinal cord and DRG following spinal injury.

    Original languageEnglish (US)
    Pages (from-to)889-893
    Number of pages5
    JournalNeuroReport
    Volume10
    Issue number4
    DOIs
    StatePublished - Mar 17 1999

    Keywords

    • Dorsal root ganglia
    • NGF
    • Nerve growth factor
    • Neurotrophin
    • Neurotropin
    • Rat, Spinal cord injury

    ASJC Scopus subject areas

    • Neuroscience(all)

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