NGF levels decrease in the spinal cord and dorsal root ganglion after spinal hemisection

Adrianne D. Bennett, Giulio Taglialatela, Regino Perez-Polo, Claire E. Hulsebosch

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

To examine changes in nerve growth factor (NGF) levels in spinal cord and dorsal root ganglia (DRG) after spinal injury, male Sprague-Dawley rats weighing 150-175 g were given spinal hemisections. NGF content was measured at various post-surgical times and compared with naive controls (n=4 per time point) in the spinal cord, DRG and blood serum by ELISA techniques (Promega). Levels of NGF in the blood serum were significantly increased 8-fold at 48 h but were significantly decreased in the spinal cord and DRG by 2- to 4-fold until 7 days postsurgery (ANOVA, p<0.05). Contrary to accepted dogma, spinal injury results in decreased levels of NGF in the spinal cord and DRG following spinal injury.

Original languageEnglish (US)
Pages (from-to)889-893
Number of pages5
JournalNeuroReport
Volume10
Issue number4
StatePublished - Mar 17 1999

Fingerprint

Spinal Nerve Roots
Spinal Ganglia
Nerve Growth Factor
Spinal Injuries
Spinal Cord
Operative Time
Serum
Sprague Dawley Rats
Analysis of Variance
Enzyme-Linked Immunosorbent Assay

Keywords

  • Dorsal root ganglia
  • Nerve growth factor
  • Neurotrophin
  • Neurotropin
  • NGF
  • Rat, Spinal cord injury

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Bennett, A. D., Taglialatela, G., Perez-Polo, R., & Hulsebosch, C. E. (1999). NGF levels decrease in the spinal cord and dorsal root ganglion after spinal hemisection. NeuroReport, 10(4), 889-893.

NGF levels decrease in the spinal cord and dorsal root ganglion after spinal hemisection. / Bennett, Adrianne D.; Taglialatela, Giulio; Perez-Polo, Regino; Hulsebosch, Claire E.

In: NeuroReport, Vol. 10, No. 4, 17.03.1999, p. 889-893.

Research output: Contribution to journalArticle

Bennett, AD, Taglialatela, G, Perez-Polo, R & Hulsebosch, CE 1999, 'NGF levels decrease in the spinal cord and dorsal root ganglion after spinal hemisection', NeuroReport, vol. 10, no. 4, pp. 889-893.
Bennett, Adrianne D. ; Taglialatela, Giulio ; Perez-Polo, Regino ; Hulsebosch, Claire E. / NGF levels decrease in the spinal cord and dorsal root ganglion after spinal hemisection. In: NeuroReport. 1999 ; Vol. 10, No. 4. pp. 889-893.
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