Nicotine reduces food-induced release of gastrin

C. Gomez, V. Udupi, I. Lambertz, X. Qi, F. L C Hill, J. G. Thompson, G. H. Greeley

    Research output: Contribution to journalArticle

    Abstract

    Nicotine1 (N) can decrease stornach gastrin gene expression in rats. The purpose of these experiments was to characterise the effect of N on f ood-s t imulatcd release of gastrin. METHOD . Adul I ma 1 e 3-D rat s were gi ven N or vehicle for t wo weeks (f>. 12 mg/kg/d) by means of SC implanted Alzet osmotic pumps. Rat s were fed AIN-'?6 or a beef tallow diet (High Fat II). Vehicl" treated rats were pair-fed accord ing to the daily food i n t nki> of N-treated rats . At the end of the two week N t reatmeni . rat s were fas ted for 24 hours . Fast cd r .it .s wore sac r i f i ccd without refeeding (BASAL) or refed. Refed rats were sacrificed at 30 and 60 mm after refeeding. Serum was co! l;cted from al 1 rat s for measurement of gastri n 1evels by radi01mmunoassay. RESULTS. N did riot affect basal gastrin levels. Food-induced release of gastrin was reduced significantly in N-1 reat ed rats. '= P<0 . 05 vs - re spec t i ve groups g i ven saline; 11= 6 - 8 rat s/groiip SERUM GASTRIN Cpg/mlJ NICOTINE(Umg/kg/di NICOTINE(6mg,/ /kg/d .' GROUP BASAL 30 MIN 60 MIN BASAL 30 MIN 60 MIN AIN 76 101111 126±7 152±7 9811? 143 ±3 195±K AIN 76+N 96±8 110±8 92±6' 8211Ü161113 14?±15 High FatII 10217 144±8 140±8 83110 137113 13 /±14 High FatII+N 10915 1121690±798113 99±13136±11 CONCLUSIONS. N decreases food-induced release of gastrin. N-induced decrease in gastrin secretion may be partly due to a N-induced élevât ion in gastric acid secretion.

    Original languageEnglish (US)
    JournalFASEB Journal
    Volume10
    Issue number3
    StatePublished - 1996

    Fingerprint

    gastrins
    nicotine
    Gastrins
    Nicotine
    Rats
    Food
    rats
    refeeding
    Riots
    secretion
    gastric acid
    tallow
    Gastric Acid
    High Fat Diet
    high fat diet
    Nutrition
    Gene expression
    pumps
    Fats
    Wear of materials

    ASJC Scopus subject areas

    • Agricultural and Biological Sciences (miscellaneous)
    • Biochemistry, Genetics and Molecular Biology(all)
    • Biochemistry
    • Cell Biology

    Cite this

    Gomez, C., Udupi, V., Lambertz, I., Qi, X., Hill, F. L. C., Thompson, J. G., & Greeley, G. H. (1996). Nicotine reduces food-induced release of gastrin. FASEB Journal, 10(3).

    Nicotine reduces food-induced release of gastrin. / Gomez, C.; Udupi, V.; Lambertz, I.; Qi, X.; Hill, F. L C; Thompson, J. G.; Greeley, G. H.

    In: FASEB Journal, Vol. 10, No. 3, 1996.

    Research output: Contribution to journalArticle

    Gomez, C, Udupi, V, Lambertz, I, Qi, X, Hill, FLC, Thompson, JG & Greeley, GH 1996, 'Nicotine reduces food-induced release of gastrin', FASEB Journal, vol. 10, no. 3.
    Gomez C, Udupi V, Lambertz I, Qi X, Hill FLC, Thompson JG et al. Nicotine reduces food-induced release of gastrin. FASEB Journal. 1996;10(3).
    Gomez, C. ; Udupi, V. ; Lambertz, I. ; Qi, X. ; Hill, F. L C ; Thompson, J. G. ; Greeley, G. H. / Nicotine reduces food-induced release of gastrin. In: FASEB Journal. 1996 ; Vol. 10, No. 3.
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    title = "Nicotine reduces food-induced release of gastrin",
    abstract = "Nicotine1 (N) can decrease stornach gastrin gene expression in rats. The purpose of these experiments was to characterise the effect of N on f ood-s t imulatcd release of gastrin. METHOD . Adul I ma 1 e 3-D rat s were gi ven N or vehicle for t wo weeks (f>. 12 mg/kg/d) by means of SC implanted Alzet osmotic pumps. Rat s were fed AIN-'?6 or a beef tallow diet (High Fat II). Vehicl{"} treated rats were pair-fed accord ing to the daily food i n t nki> of N-treated rats . At the end of the two week N t reatmeni . rat s were fas ted for 24 hours . Fast cd r .it .s wore sac r i f i ccd without refeeding (BASAL) or refed. Refed rats were sacrificed at 30 and 60 mm after refeeding. Serum was co! l;cted from al 1 rat s for measurement of gastri n 1evels by radi01mmunoassay. RESULTS. N did riot affect basal gastrin levels. Food-induced release of gastrin was reduced significantly in N-1 reat ed rats. '= P<0 . 05 vs - re spec t i ve groups g i ven saline; 11= 6 - 8 rat s/groiip SERUM GASTRIN Cpg/mlJ NICOTINE(Umg/kg/di NICOTINE(6mg,/ /kg/d .' GROUP BASAL 30 MIN 60 MIN BASAL 30 MIN 60 MIN AIN 76 101111 126±7 152±7 9811? 143 ±3 195±K AIN 76+N 96±8 110±8 92±6' 8211{\"U}161113 14?±15 High FatII 10217 144±8 140±8 83110 137113 13 /±14 High FatII+N 10915 1121690±798113 99±13136±11 CONCLUSIONS. N decreases food-induced release of gastrin. N-induced decrease in gastrin secretion may be partly due to a N-induced {\'e}lev{\^a}t ion in gastric acid secretion.",
    author = "C. Gomez and V. Udupi and I. Lambertz and X. Qi and Hill, {F. L C} and Thompson, {J. G.} and Greeley, {G. H.}",
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    T1 - Nicotine reduces food-induced release of gastrin

    AU - Gomez, C.

    AU - Udupi, V.

    AU - Lambertz, I.

    AU - Qi, X.

    AU - Hill, F. L C

    AU - Thompson, J. G.

    AU - Greeley, G. H.

    PY - 1996

    Y1 - 1996

    N2 - Nicotine1 (N) can decrease stornach gastrin gene expression in rats. The purpose of these experiments was to characterise the effect of N on f ood-s t imulatcd release of gastrin. METHOD . Adul I ma 1 e 3-D rat s were gi ven N or vehicle for t wo weeks (f>. 12 mg/kg/d) by means of SC implanted Alzet osmotic pumps. Rat s were fed AIN-'?6 or a beef tallow diet (High Fat II). Vehicl" treated rats were pair-fed accord ing to the daily food i n t nki> of N-treated rats . At the end of the two week N t reatmeni . rat s were fas ted for 24 hours . Fast cd r .it .s wore sac r i f i ccd without refeeding (BASAL) or refed. Refed rats were sacrificed at 30 and 60 mm after refeeding. Serum was co! l;cted from al 1 rat s for measurement of gastri n 1evels by radi01mmunoassay. RESULTS. N did riot affect basal gastrin levels. Food-induced release of gastrin was reduced significantly in N-1 reat ed rats. '= P<0 . 05 vs - re spec t i ve groups g i ven saline; 11= 6 - 8 rat s/groiip SERUM GASTRIN Cpg/mlJ NICOTINE(Umg/kg/di NICOTINE(6mg,/ /kg/d .' GROUP BASAL 30 MIN 60 MIN BASAL 30 MIN 60 MIN AIN 76 101111 126±7 152±7 9811? 143 ±3 195±K AIN 76+N 96±8 110±8 92±6' 8211Ü161113 14?±15 High FatII 10217 144±8 140±8 83110 137113 13 /±14 High FatII+N 10915 1121690±798113 99±13136±11 CONCLUSIONS. N decreases food-induced release of gastrin. N-induced decrease in gastrin secretion may be partly due to a N-induced élevât ion in gastric acid secretion.

    AB - Nicotine1 (N) can decrease stornach gastrin gene expression in rats. The purpose of these experiments was to characterise the effect of N on f ood-s t imulatcd release of gastrin. METHOD . Adul I ma 1 e 3-D rat s were gi ven N or vehicle for t wo weeks (f>. 12 mg/kg/d) by means of SC implanted Alzet osmotic pumps. Rat s were fed AIN-'?6 or a beef tallow diet (High Fat II). Vehicl" treated rats were pair-fed accord ing to the daily food i n t nki> of N-treated rats . At the end of the two week N t reatmeni . rat s were fas ted for 24 hours . Fast cd r .it .s wore sac r i f i ccd without refeeding (BASAL) or refed. Refed rats were sacrificed at 30 and 60 mm after refeeding. Serum was co! l;cted from al 1 rat s for measurement of gastri n 1evels by radi01mmunoassay. RESULTS. N did riot affect basal gastrin levels. Food-induced release of gastrin was reduced significantly in N-1 reat ed rats. '= P<0 . 05 vs - re spec t i ve groups g i ven saline; 11= 6 - 8 rat s/groiip SERUM GASTRIN Cpg/mlJ NICOTINE(Umg/kg/di NICOTINE(6mg,/ /kg/d .' GROUP BASAL 30 MIN 60 MIN BASAL 30 MIN 60 MIN AIN 76 101111 126±7 152±7 9811? 143 ±3 195±K AIN 76+N 96±8 110±8 92±6' 8211Ü161113 14?±15 High FatII 10217 144±8 140±8 83110 137113 13 /±14 High FatII+N 10915 1121690±798113 99±13136±11 CONCLUSIONS. N decreases food-induced release of gastrin. N-induced decrease in gastrin secretion may be partly due to a N-induced élevât ion in gastric acid secretion.

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