Nicotinic acetylcholine receptors in alzheimer's and Parkinson's disease

Kelly T. Dineley

doi:10.1007/978-1-4939-1167-7_19

Nicotinic acetylcholine receptors in alzheimer's and Parkinson's disease

Kelly T. Dineley

Neurology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Abstract In the CNS, nicotinic acetylcholine receptors prominent roles in modulating presynaptic and postsynaptic signaling and have been implicated in several CNS disorders including the two most prominent neurodegenerative diseases: Alzheimer's disease and Parkinson's disease. These neurodegenerative diseases affect scores of millions of persons worldwide with their prevalence increasing as human longevity increases. This chapter will provide an overview of Alzheimer's disease and Parkinson's disease, the cholinergic system affected in each disorder, and the types of nicotinic acetylcholine receptors affected during disease progression. Finally, a discussion of therapeutic strategies targeting nicotinic acetylcholine receptors is included based upon the most current preclinical and clinical research.

Original language	English (US)
Title of host publication	Nicotinic Receptors
Publisher	Springer New York
Pages	383-415
Number of pages	33
ISBN (Electronic)	9781493911677
ISBN (Print)	9781493911660
DOIs	https://doi.org/10.1007/978-1-4939-1167-7_19
State	Published - Jan 1 2014

Keywords

Acetylcholine
Basal forebrain cholinergic system
Cholinergic
Dopamine
Hippocampus
Neurodegeneration
Striatum
Substantia nigra

ASJC Scopus subject areas

General Medicine
General Neuroscience

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10.1007/978-1-4939-1167-7_19

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AB - Abstract In the CNS, nicotinic acetylcholine receptors prominent roles in modulating presynaptic and postsynaptic signaling and have been implicated in several CNS disorders including the two most prominent neurodegenerative diseases: Alzheimer's disease and Parkinson's disease. These neurodegenerative diseases affect scores of millions of persons worldwide with their prevalence increasing as human longevity increases. This chapter will provide an overview of Alzheimer's disease and Parkinson's disease, the cholinergic system affected in each disorder, and the types of nicotinic acetylcholine receptors affected during disease progression. Finally, a discussion of therapeutic strategies targeting nicotinic acetylcholine receptors is included based upon the most current preclinical and clinical research.

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KW - Dopamine

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KW - Neurodegeneration

KW - Striatum

KW - Substantia nigra

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Nicotinic acetylcholine receptors in alzheimer's and Parkinson's disease

Abstract

Keywords

ASJC Scopus subject areas

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