Abstract In the CNS, nicotinic acetylcholine receptors prominent roles in modulating presynaptic and postsynaptic signaling and have been implicated in several CNS disorders including the two most prominent neurodegenerative diseases: Alzheimer's disease and Parkinson's disease. These neurodegenerative diseases affect scores of millions of persons worldwide with their prevalence increasing as human longevity increases. This chapter will provide an overview of Alzheimer's disease and Parkinson's disease, the cholinergic system affected in each disorder, and the types of nicotinic acetylcholine receptors affected during disease progression. Finally, a discussion of therapeutic strategies targeting nicotinic acetylcholine receptors is included based upon the most current preclinical and clinical research.
- Basal forebrain cholinergic system
- Substantia nigra
ASJC Scopus subject areas