Nicotinic acetylcholine receptors in alzheimer's and Parkinson's disease

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Abstract In the CNS, nicotinic acetylcholine receptors prominent roles in modulating presynaptic and postsynaptic signaling and have been implicated in several CNS disorders including the two most prominent neurodegenerative diseases: Alzheimer's disease and Parkinson's disease. These neurodegenerative diseases affect scores of millions of persons worldwide with their prevalence increasing as human longevity increases. This chapter will provide an overview of Alzheimer's disease and Parkinson's disease, the cholinergic system affected in each disorder, and the types of nicotinic acetylcholine receptors affected during disease progression. Finally, a discussion of therapeutic strategies targeting nicotinic acetylcholine receptors is included based upon the most current preclinical and clinical research.

Original languageEnglish (US)
Title of host publicationNicotinic Receptors
PublisherSpringer New York
Pages383-415
Number of pages33
ISBN (Electronic)9781493911677
ISBN (Print)9781493911660
DOIs
StatePublished - Jan 1 2014

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Keywords

  • Acetylcholine
  • Basal forebrain cholinergic system
  • Cholinergic
  • Dopamine
  • Hippocampus
  • Neurodegeneration
  • Striatum
  • Substantia nigra

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

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