Nipah virus-associated encephalitis outbreak, Siliguri, India

Mandeep S. Chadha, James A. Comer, Luis Lowe, Paul A. Rota, Pierre E. Rollin, William J. Bellini, Thomas Ksiazek, Akhilesh C. Mishra

Research output: Contribution to journalArticle

283 Citations (Scopus)

Abstract

During January and February 2001, an outbreak of febrile illness associated with altered sensorium was observed in Siliguri, West Bengal, India. Laboratory investigations at the time of the outbreak did not identify an infectious agent. Because Siliguri is in close proximity to Bangladesh, where outbreaks of Nipah virus (NiV) infection were recently described, clinical material obtained during the Siliguri outbreak was retrospectively analyzed for evidence of NiV infection. NiV-specific immunoglobulin M (IgM) and IgG antibodies were detected in 9 of 18 patients. Reverse transcription-polymerase chain reaction (RTPCR) assays detected RNA from NiV in urine samples from 5 patients. Sequence analysis confirmed that the PCR products were derived from NiV RNA and suggested that the NiV from Siliguri was more closely related to NiV isolates from Bangladesh than to NiV isolates from Malaysia. NiV infection has not been previously detected in India.

Original languageEnglish (US)
Pages (from-to)235-240
Number of pages6
JournalEmerging Infectious Diseases
Volume12
Issue number2
StatePublished - Feb 2006
Externally publishedYes

Fingerprint

Nipah Virus
Encephalitis
Disease Outbreaks
India
Virus Diseases
Bangladesh
Polymerase Chain Reaction
RNA Viruses
Malaysia
Reverse Transcription
Immunoglobulin M
Sequence Analysis
Fever
Immunoglobulin G
Urine

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Chadha, M. S., Comer, J. A., Lowe, L., Rota, P. A., Rollin, P. E., Bellini, W. J., ... Mishra, A. C. (2006). Nipah virus-associated encephalitis outbreak, Siliguri, India. Emerging Infectious Diseases, 12(2), 235-240.

Nipah virus-associated encephalitis outbreak, Siliguri, India. / Chadha, Mandeep S.; Comer, James A.; Lowe, Luis; Rota, Paul A.; Rollin, Pierre E.; Bellini, William J.; Ksiazek, Thomas; Mishra, Akhilesh C.

In: Emerging Infectious Diseases, Vol. 12, No. 2, 02.2006, p. 235-240.

Research output: Contribution to journalArticle

Chadha, MS, Comer, JA, Lowe, L, Rota, PA, Rollin, PE, Bellini, WJ, Ksiazek, T & Mishra, AC 2006, 'Nipah virus-associated encephalitis outbreak, Siliguri, India', Emerging Infectious Diseases, vol. 12, no. 2, pp. 235-240.
Chadha MS, Comer JA, Lowe L, Rota PA, Rollin PE, Bellini WJ et al. Nipah virus-associated encephalitis outbreak, Siliguri, India. Emerging Infectious Diseases. 2006 Feb;12(2):235-240.
Chadha, Mandeep S. ; Comer, James A. ; Lowe, Luis ; Rota, Paul A. ; Rollin, Pierre E. ; Bellini, William J. ; Ksiazek, Thomas ; Mishra, Akhilesh C. / Nipah virus-associated encephalitis outbreak, Siliguri, India. In: Emerging Infectious Diseases. 2006 ; Vol. 12, No. 2. pp. 235-240.
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