Nitazoxanide

A new broad spectrum antiparasitic agent

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Nitazoxanide (Alinia®, Romark Laboratories) was synthesized based on the structure of niclosamide. In vitro studies have demonstrated activity against a broad range of parasites as well as some bacteria. Three controlled trials demonstrated efficacy in cryptosporidiosis, however, the efficacy in advanced AIDS patients (CD4 cell counts = 50) at approved doses was limited. Trials have also demonstrated efficacy comparable to metronidazole (Flagyl®, GD Searle and Co.) in giardiasis with fewer side effects. Nitazoxanide is also effective versus intestinal helminths and tapeworms as well as in chronic fascioliasis. Side effects in clinical trials have been similar to placebo. Nitazoxanide is the first agent proven to be effective in cryptosporidiosis. It has also proven efficacy in giardiasis. Nitazoxanide is efficacious again intestinal helminths. Additional indications may be developed in the future.

Original languageEnglish (US)
Pages (from-to)43-50
Number of pages8
JournalExpert Review of Anti-Infective Therapy
Volume2
Issue number1
StatePublished - Feb 2004
Externally publishedYes

Fingerprint

nitazoxanide
Antiparasitic Agents
Cryptosporidiosis
Giardiasis
Helminths
Metronidazole
Niclosamide
Fascioliasis
Cestoda
CD4 Lymphocyte Count
Parasites
Acquired Immunodeficiency Syndrome
Placebos
Clinical Trials
Bacteria

Keywords

  • Antiparasitic
  • Cryptosporidiosis
  • Cryptosporidium
  • Echinococcus
  • Fasciola
  • Giardia
  • Helminth

ASJC Scopus subject areas

  • Infectious Diseases
  • Parasitology

Cite this

Nitazoxanide : A new broad spectrum antiparasitic agent. / White, A. Clinton.

In: Expert Review of Anti-Infective Therapy, Vol. 2, No. 1, 02.2004, p. 43-50.

Research output: Contribution to journalArticle

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