Nitric Oxide as a Determinant of Human Longevity and Health Span

Burkhard Poeggeler, Sandeep Kumar Singh, Kumar Sambamurti, Miguel A. Pappolla

Research output: Contribution to journalReview articlepeer-review


The master molecular regulators and mechanisms determining longevity and health span include nitric oxide (NO) and superoxide anion radicals (SOR). L-arginine, the NO synthase (NOS) substrate, can restore a healthy ratio between the dangerous SOR and the protective NO radical to promote healthy aging. Antioxidant supplementation orchestrates protection against oxidative stress and damage—L-arginine and antioxidants such as vitamin C increase NO production and bioavailability. Uncoupling of NO generation with the appearance of SOR can be induced by asymmetric dimethylarginine (ADMA). L-arginine can displace ADMA from the site of NO formation if sufficient amounts of the amino acid are available. Antioxidants such as ascorbic acids can scavenge SOR and increase the bioavailability of NO. The topics of this review are the complex interactions of antioxidant agents with L-arginine, which determine NO bioactivity and protection against age-related degeneration.

Original languageEnglish (US)
Article number14533
JournalInternational journal of molecular sciences
Issue number19
StatePublished - Oct 2023
Externally publishedYes


  • aging
  • amino acids
  • antioxidant
  • arginine
  • nitric oxide
  • oxidative stress
  • peptide
  • protein

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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