Nitric oxide mediates mechano- and chemoreceptor-activated intestinal feedback control of gastric emptying

Michihiro Orihata, Sushil K. Sarna

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

The effect of nitric oxide (NO) synthase inhibition on the gastric emptying of nutrient and non-nutrient meals was investigated in nine dogs. The inhibition of NO synthase delayed the gastric emptying time of both nutrient and non-nutrient meals, but the percentage delay of nutrient meals was significantly greater than that of non-nutrient meals. The inhibition of NO synthase during the emptying of non-nutrient meals enhanced mainly the amplitude of antral, pyloric, and distal duodenal contractions. However, NO synthase inhibition during the emptying of nutrient meals stimulated several spatial and temporal parameters of gastropyloroduodenal contractions. We conclude that NO is one of the neurotransmitters of intestinal feedback that regulates the gastric emptying of both nutrient and non-nutrient meals. The nature and intensity of intestinal feedback by the stimulation of both chemo- and mechanoreceptors by nutrient meals is different from that by the stimulation of mechanoreceptors only by the non-nutrient meals.

Original languageEnglish (US)
Pages (from-to)1303-1309
Number of pages7
JournalDigestive Diseases and Sciences
Volume41
Issue number7
DOIs
StatePublished - 1996

Keywords

  • motility
  • nitric oxide
  • nonadrenergic
  • noncholinergic neurons

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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