Nitrogen utilization from elemental diets

J. E. Albina, D. O. Jacobs, G. Melnik, R. G. Settle, T. P. Stein, D. Guy, J. L. Rombeau

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Repletion experiments were performed in malnourished, chair-adapted primates to explore recently reported differences in nitrogen utilization from elemental diets. Two elemental diets were fed consecutively for 8 days through a gastrostomy. Diet C (maltodextrins, peptides, crystalline amino acids) resulted in: larger weight gain (F1,6 = 17.93, p < 0.01); smaller decrease of serum albumin (F1,5 = 11.2, p 0.015), larger increase in total iron binding capacity (F1,6 = 30.6, p < 0.002), and a more positive nitrogen balance (F1,6 = 30.4, p < 0.002) than diet V (glucose oligosaccharides, crystalline amino acids). Diet C was considered to be more effective in the nutritional repletion of the study animals. Additional experiments were performed in normal human volunteers to investigate the metabolic fate of ingested glutamine and whether the rapid catabolism and excretion of the amino nitrogen of this amino acid, which constitutes 11.56% of total nitrogen in diet V, could explain the differences observed in primates in our study and in human subjects by other authors. Six normal volunteers were fed 15N amino glutamine, 15N alanine, or 15N H4Cl. Similar amounts of 15N from Gln and Ala were excreted in 10 hr. The amino group of glutamine does not seem to be metabolized differently from the α-amino group of alanine under the conditions of the study. The marked differences in nitrogen utilization from the study diets could not be explained by the presence of relatively large amounts of glutamine in one of them.

Original languageEnglish (US)
Pages (from-to)189-195
Number of pages7
JournalJournal of Parenteral and Enteral Nutrition
Volume9
Issue number2
StatePublished - 1985
Externally publishedYes

Fingerprint

Formulated Food
Glutamine
Nitrogen
Diet
glutamine
nitrogen
diet
Amino Acids
repletion
Alanine
Primates
Healthy Volunteers
alanine
amino acids
volunteers
Gastrostomy
amino nitrogen
Oligosaccharides
maltodextrins
Serum Albumin

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Albina, J. E., Jacobs, D. O., Melnik, G., Settle, R. G., Stein, T. P., Guy, D., & Rombeau, J. L. (1985). Nitrogen utilization from elemental diets. Journal of Parenteral and Enteral Nutrition, 9(2), 189-195.

Nitrogen utilization from elemental diets. / Albina, J. E.; Jacobs, D. O.; Melnik, G.; Settle, R. G.; Stein, T. P.; Guy, D.; Rombeau, J. L.

In: Journal of Parenteral and Enteral Nutrition, Vol. 9, No. 2, 1985, p. 189-195.

Research output: Contribution to journalArticle

Albina, JE, Jacobs, DO, Melnik, G, Settle, RG, Stein, TP, Guy, D & Rombeau, JL 1985, 'Nitrogen utilization from elemental diets', Journal of Parenteral and Enteral Nutrition, vol. 9, no. 2, pp. 189-195.
Albina JE, Jacobs DO, Melnik G, Settle RG, Stein TP, Guy D et al. Nitrogen utilization from elemental diets. Journal of Parenteral and Enteral Nutrition. 1985;9(2):189-195.
Albina, J. E. ; Jacobs, D. O. ; Melnik, G. ; Settle, R. G. ; Stein, T. P. ; Guy, D. ; Rombeau, J. L. / Nitrogen utilization from elemental diets. In: Journal of Parenteral and Enteral Nutrition. 1985 ; Vol. 9, No. 2. pp. 189-195.
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