Nitrosative stress and pharmacological modulation of heart failure

Pal Pacher, Richard Schulz, Lucas Liaudet, Csaba Szabo

Research output: Contribution to journalArticle

185 Citations (Scopus)

Abstract

Dysregulation of nitric oxide (NO) and increased oxidative and nitrosative stress are implicated in the pathogenesis of heart failure. Peroxynitrite is a reactive oxidant that is produced from the reaction of nitric oxide with superoxide anion and impairs cardiovascular function through multiple mechanisms, including activation of matrix metalloproteinases (MMPs) and nuclear enzyme poly(ADP-ribose) polymerase (PARP). Recent studies suggest that the neutralization of peroxynitrite or pharmacological inhibition of MMPs and PARP are promising new approaches in the experimental therapy of various forms of myocardial injury. In this article, the role of nitrosative stress and downstream mechanisms, including activation of MMPs and PARP, in various forms of heart failure are discussed and novel emerging therapeutic strategies offered by neutralization of peroxynitrite and inhibition of MMPs and PARP in these pathophysiological conditions are reviewed.

Original languageEnglish (US)
Pages (from-to)302-310
Number of pages9
JournalTrends in Pharmacological Sciences
Volume26
Issue number6
DOIs
StatePublished - Jun 2005
Externally publishedYes

Fingerprint

Poly(ADP-ribose) Polymerases
Matrix Metalloproteinases
Peroxynitrous Acid
Heart Failure
Modulation
Pharmacology
Nitric Oxide
Chemical activation
Investigational Therapies
Oxidants
Superoxides
Oxidative Stress
Wounds and Injuries
Enzymes
Therapeutics

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Nitrosative stress and pharmacological modulation of heart failure. / Pacher, Pal; Schulz, Richard; Liaudet, Lucas; Szabo, Csaba.

In: Trends in Pharmacological Sciences, Vol. 26, No. 6, 06.2005, p. 302-310.

Research output: Contribution to journalArticle

Pacher, Pal ; Schulz, Richard ; Liaudet, Lucas ; Szabo, Csaba. / Nitrosative stress and pharmacological modulation of heart failure. In: Trends in Pharmacological Sciences. 2005 ; Vol. 26, No. 6. pp. 302-310.
@article{6969b689efd34db68f9cc1617b96c953,
title = "Nitrosative stress and pharmacological modulation of heart failure",
abstract = "Dysregulation of nitric oxide (NO) and increased oxidative and nitrosative stress are implicated in the pathogenesis of heart failure. Peroxynitrite is a reactive oxidant that is produced from the reaction of nitric oxide with superoxide anion and impairs cardiovascular function through multiple mechanisms, including activation of matrix metalloproteinases (MMPs) and nuclear enzyme poly(ADP-ribose) polymerase (PARP). Recent studies suggest that the neutralization of peroxynitrite or pharmacological inhibition of MMPs and PARP are promising new approaches in the experimental therapy of various forms of myocardial injury. In this article, the role of nitrosative stress and downstream mechanisms, including activation of MMPs and PARP, in various forms of heart failure are discussed and novel emerging therapeutic strategies offered by neutralization of peroxynitrite and inhibition of MMPs and PARP in these pathophysiological conditions are reviewed.",
author = "Pal Pacher and Richard Schulz and Lucas Liaudet and Csaba Szabo",
year = "2005",
month = "6",
doi = "10.1016/j.tips.2005.04.003",
language = "English (US)",
volume = "26",
pages = "302--310",
journal = "Trends in Pharmacological Sciences",
issn = "0165-6147",
publisher = "Elsevier Limited",
number = "6",

}

TY - JOUR

T1 - Nitrosative stress and pharmacological modulation of heart failure

AU - Pacher, Pal

AU - Schulz, Richard

AU - Liaudet, Lucas

AU - Szabo, Csaba

PY - 2005/6

Y1 - 2005/6

N2 - Dysregulation of nitric oxide (NO) and increased oxidative and nitrosative stress are implicated in the pathogenesis of heart failure. Peroxynitrite is a reactive oxidant that is produced from the reaction of nitric oxide with superoxide anion and impairs cardiovascular function through multiple mechanisms, including activation of matrix metalloproteinases (MMPs) and nuclear enzyme poly(ADP-ribose) polymerase (PARP). Recent studies suggest that the neutralization of peroxynitrite or pharmacological inhibition of MMPs and PARP are promising new approaches in the experimental therapy of various forms of myocardial injury. In this article, the role of nitrosative stress and downstream mechanisms, including activation of MMPs and PARP, in various forms of heart failure are discussed and novel emerging therapeutic strategies offered by neutralization of peroxynitrite and inhibition of MMPs and PARP in these pathophysiological conditions are reviewed.

AB - Dysregulation of nitric oxide (NO) and increased oxidative and nitrosative stress are implicated in the pathogenesis of heart failure. Peroxynitrite is a reactive oxidant that is produced from the reaction of nitric oxide with superoxide anion and impairs cardiovascular function through multiple mechanisms, including activation of matrix metalloproteinases (MMPs) and nuclear enzyme poly(ADP-ribose) polymerase (PARP). Recent studies suggest that the neutralization of peroxynitrite or pharmacological inhibition of MMPs and PARP are promising new approaches in the experimental therapy of various forms of myocardial injury. In this article, the role of nitrosative stress and downstream mechanisms, including activation of MMPs and PARP, in various forms of heart failure are discussed and novel emerging therapeutic strategies offered by neutralization of peroxynitrite and inhibition of MMPs and PARP in these pathophysiological conditions are reviewed.

UR - http://www.scopus.com/inward/record.url?scp=19544392527&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=19544392527&partnerID=8YFLogxK

U2 - 10.1016/j.tips.2005.04.003

DO - 10.1016/j.tips.2005.04.003

M3 - Article

VL - 26

SP - 302

EP - 310

JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

SN - 0165-6147

IS - 6

ER -