NMDA receptor activation stimulates transcription-independent rapid wnt5a protein synthesis via the MAPK signaling pathway

Yichen Li, Bei Li, Xianzi Wan, Wei Zhang, Ling Zhong, Shao-Jun Tang

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Wnt proteins are emerging key regulators of the plasticity and functions of adult brains. However, the mechanisms by which the expression of Wnt proteins is regulated in neurons are unclear. Using cortical primary cultures, we show here that activation of NMDA receptors (NMDARs) induces rapid Wnt5a protein synthesis and secretion. This NMDAR-regulated Wnt5a synthesis does not require transcription and is a result of activity-dependent translation. We also show that NMDAR-regulated Wnt5a translation depends on MAPK signaling but not mTOR signaling. Our findings suggest that the synaptic activity of CNS neurons activates NMDARs, which in turn stimulate translation from stored Wnt5a mRNA via the MAPK signaling pathway.

Original languageEnglish (US)
Article number1
JournalMolecular Brain
Volume5
Issue number1
DOIs
StatePublished - 2012

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N-Methyl-D-Aspartate Receptors
Transcriptional Activation
Wnt Proteins
Stored Messenger RNA
Neurons
Wnt-5a Protein
Brain

Keywords

  • activity-regulated protein synthesis
  • MAPK signaling
  • mTOR signaling
  • NMDA receptors
  • Wnt protein

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Molecular Biology

Cite this

NMDA receptor activation stimulates transcription-independent rapid wnt5a protein synthesis via the MAPK signaling pathway. / Li, Yichen; Li, Bei; Wan, Xianzi; Zhang, Wei; Zhong, Ling; Tang, Shao-Jun.

In: Molecular Brain, Vol. 5, No. 1, 1, 2012.

Research output: Contribution to journalArticle

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AU - Tang, Shao-Jun

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