NMDA receptors and colitis: Basic science and clinical implications

QiQi Zhou, G. Nicholas Verne

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

During the last decade, research focusing primarily on alterations in the peripheral and central nervous system has improved our understanding of the pathophysiological mechanisms of chronic visceral pain. These studies have demonstrated significant physiological changes following injury to the viscera in the firing patterns of both primary afferent neurons that transmit nociceptive information from the viscera and in central neurons that process the nociceptive information. A number of receptors, neurotransmitters, cytokines, and second messenger systems in these neurons have been implicated in the enhancement of visceral nociception. N-methyl-D-aspartic acid (NMDA) receptors play an important role in chronic visceral pain and hypersensitivity that is present in the setting of colonic inflammation. NMDA receptors are found in the peripheral nervous system as well as the central terminal of primary afferent neurons and have been shown to play an important role in regulating the release of nociceptive neurotransmitters. Recent work has demonstrated the presence of NMDA receptors in the enteric nervous system. In this article, we will discuss more recent evidence of the role of NMDA receptors in visceral pain associated with colitis.

Original languageEnglish (US)
Pages (from-to)33-43
Number of pages11
JournalReviews in Analgesia
Volume10
Issue number1
StatePublished - 2008

Fingerprint

N-Methylaspartate
Visceral Pain
Colitis
Afferent Neurons
Viscera
Peripheral Nervous System
Chronic Pain
Enteric Nervous System
Nociceptors
Neurotransmitter Receptor
Cytokine Receptors
Nociception
Second Messenger Systems
Neurotransmitter Agents
Hypersensitivity
Central Nervous System
Inflammation
Neurons
aspartic acid receptor
Wounds and Injuries

Keywords

  • Colitis
  • NMDA receptor
  • Visceral hypersensitivity
  • Visceral pain

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

NMDA receptors and colitis : Basic science and clinical implications. / Zhou, QiQi; Verne, G. Nicholas.

In: Reviews in Analgesia, Vol. 10, No. 1, 2008, p. 33-43.

Research output: Contribution to journalArticle

Zhou, Q & Verne, GN 2008, 'NMDA receptors and colitis: Basic science and clinical implications', Reviews in Analgesia, vol. 10, no. 1, pp. 33-43.
Zhou, QiQi ; Verne, G. Nicholas. / NMDA receptors and colitis : Basic science and clinical implications. In: Reviews in Analgesia. 2008 ; Vol. 10, No. 1. pp. 33-43.
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