NMR structure of an oligonucleotide containing a base pair 3-(2- hydroxyethyl) deoxyuridine-adenine

Y. Boulard, Lawrence Sowers, G. V. Fazakerley

Research output: Contribution to journalArticle

Abstract

It has been shown that ethylene oxide reacts with dC at the N3 position to produce a potentially mutagenic lesion, 3-(2-hydroxyethyl) deoxyuridine (3-HE-dU). In this article, we report NMR and Molecular Mechanic studies of a duplex containing the 3-HE-dU base with an adenine in front of the lesion which is in the sequence, 5'-GCAAGTC(3-HE-dU)AAAACG.

Original languageEnglish (US)
Pages (from-to)1603-1607
Number of pages5
JournalNucleosides and Nucleotides
Volume18
Issue number6-7
StatePublished - 1999
Externally publishedYes

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Deoxyuridine
Adenine
Oligonucleotides
Base Pairing
Nuclear magnetic resonance
Ethylene Oxide
Molecular mechanics
3-(2-hydroxyethyl)adenine

ASJC Scopus subject areas

  • Biochemistry
  • Genetics

Cite this

NMR structure of an oligonucleotide containing a base pair 3-(2- hydroxyethyl) deoxyuridine-adenine. / Boulard, Y.; Sowers, Lawrence; Fazakerley, G. V.

In: Nucleosides and Nucleotides, Vol. 18, No. 6-7, 1999, p. 1603-1607.

Research output: Contribution to journalArticle

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