NMR structure of an oligonucleotide containing a base pair 3-(2- hydroxyethyl) deoxyuridine-adenine

Y. Boulard; L. C. Sowers; G. V. Fazakerley

doi:10.1080/07328319908044797

NMR structure of an oligonucleotide containing a base pair 3-(2- hydroxyethyl) deoxyuridine-adenine

Y. Boulard, L. C. Sowers, G. V. Fazakerley

Research output: Contribution to journal › Article › peer-review

Abstract

It has been shown that ethylene oxide reacts with dC at the N3 position to produce a potentially mutagenic lesion, 3-(2-hydroxyethyl) deoxyuridine (3-HE-dU). In this article, we report NMR and Molecular Mechanic studies of a duplex containing the 3-HE-dU base with an adenine in front of the lesion which is in the sequence, 5'-GCAAGTC(3-HE-dU)AAAACG.

Original language	English (US)
Pages (from-to)	1603-1607
Number of pages	5
Journal	Nucleosides and Nucleotides
Volume	18
Issue number	6-7
DOIs	https://doi.org/10.1080/07328319908044797
State	Published - 1999
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Genetics

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10.1080/07328319908044797

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abstract = "It has been shown that ethylene oxide reacts with dC at the N3 position to produce a potentially mutagenic lesion, 3-(2-hydroxyethyl) deoxyuridine (3-HE-dU). In this article, we report NMR and Molecular Mechanic studies of a duplex containing the 3-HE-dU base with an adenine in front of the lesion which is in the sequence, 5'-GCAAGTC(3-HE-dU)AAAACG.",

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year = "1999",

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AU - Boulard, Y.

AU - Sowers, L. C.

AU - Fazakerley, G. V.

PY - 1999

Y1 - 1999

N2 - It has been shown that ethylene oxide reacts with dC at the N3 position to produce a potentially mutagenic lesion, 3-(2-hydroxyethyl) deoxyuridine (3-HE-dU). In this article, we report NMR and Molecular Mechanic studies of a duplex containing the 3-HE-dU base with an adenine in front of the lesion which is in the sequence, 5'-GCAAGTC(3-HE-dU)AAAACG.

AB - It has been shown that ethylene oxide reacts with dC at the N3 position to produce a potentially mutagenic lesion, 3-(2-hydroxyethyl) deoxyuridine (3-HE-dU). In this article, we report NMR and Molecular Mechanic studies of a duplex containing the 3-HE-dU base with an adenine in front of the lesion which is in the sequence, 5'-GCAAGTC(3-HE-dU)AAAACG.

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DO - 10.1080/07328319908044797

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JF - Nucleosides and Nucleotides

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ER -

NMR structure of an oligonucleotide containing a base pair 3-(2- hydroxyethyl) deoxyuridine-adenine

Abstract

ASJC Scopus subject areas

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