It has been shown that ethylene oxide reacts with dC at the N3 position to produce a potentially mutagenic lesion, 3-(2-hydroxyethyl) deoxyuridine (3-HE-dU). In this article, we report NMR and Molecular Mechanic studies of a duplex containing the 3-HE-dU base with an adenine in front of the lesion which is in the sequence, 5'-GCAAGTC(3-HE-dU)AAAACG.
|Original language||English (US)|
|Number of pages||5|
|Journal||Nucleosides and Nucleotides|
|State||Published - Jan 1 1999|
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