Nociceptive integration

Does it have a peripheral component?

S. M. Carlton, R. E. Coggeshall

    Research output: Contribution to journalArticle

    28 Citations (Scopus)

    Abstract

    The spinal cord dorsal horn is generally regarded as the first site where modulation and integration of nociceptive input occur. It is rare that nociceptive terminals and axons are given any greater role than being transducers and conduits. It is our hypothesis that this view of peripheral nociceptors is oversimplified and that peripheral sensory processing rivals the complexity of central spinal cord processing. The complexity of peripheral organization is supported by (1) the presence of a variety of peripheral receptors and ligands, (2) the probability that differential transport of receptors occurs with dorsal root ganglion cells, and (3) evidence that nociceptive input can be modified and integrated in the periphery before being transmitted centrally. It is hoped that unraveling the complexities of peripheral sensory processing will lead to new insights for pain therapy.

    Original languageEnglish (US)
    Pages (from-to)71-89
    Number of pages19
    JournalPain Forum
    Volume7
    Issue number2
    StatePublished - 1998

    Fingerprint

    Nociceptors
    Presynaptic Terminals
    Spinal Ganglia
    Transducers
    Spinal Cord
    Ligands
    Pain
    Therapeutics
    Spinal Cord Dorsal Horn

    Keywords

    • Pain
    • Primary afferents
    • Somatosensation
    • Transduction

    ASJC Scopus subject areas

    • Anesthesiology and Pain Medicine
    • Clinical Neurology
    • Neuroscience(all)

    Cite this

    Carlton, S. M., & Coggeshall, R. E. (1998). Nociceptive integration: Does it have a peripheral component? Pain Forum, 7(2), 71-89.

    Nociceptive integration : Does it have a peripheral component? / Carlton, S. M.; Coggeshall, R. E.

    In: Pain Forum, Vol. 7, No. 2, 1998, p. 71-89.

    Research output: Contribution to journalArticle

    Carlton, SM & Coggeshall, RE 1998, 'Nociceptive integration: Does it have a peripheral component?', Pain Forum, vol. 7, no. 2, pp. 71-89.
    Carlton, S. M. ; Coggeshall, R. E. / Nociceptive integration : Does it have a peripheral component?. In: Pain Forum. 1998 ; Vol. 7, No. 2. pp. 71-89.
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