TY - JOUR
T1 - Nociceptive primary afferents
T2 - They have a mind of their own
AU - Carlton, Susan M.
PY - 2014/8/15
Y1 - 2014/8/15
N2 - Nociceptive primary afferents have three surprising properties: they are highly complex in their expression of neurotransmitters and receptors and most probably participate in autocrine and paracrine interactions; they are capable of exerting tonic and activity-dependent inhibitory control over incoming nociceptive input; they can generate signals in the form of dorsal root reflexes that are transmitted antidromically out to the periphery and these signals can result in neurogenic inflammation in the innervated tissue. Thus, nociceptive primary afferents are highly complicated structures, capable of modifying input before it is ever transmitted to the central nervous system and capable of altering the tissue they innervate.
AB - Nociceptive primary afferents have three surprising properties: they are highly complex in their expression of neurotransmitters and receptors and most probably participate in autocrine and paracrine interactions; they are capable of exerting tonic and activity-dependent inhibitory control over incoming nociceptive input; they can generate signals in the form of dorsal root reflexes that are transmitted antidromically out to the periphery and these signals can result in neurogenic inflammation in the innervated tissue. Thus, nociceptive primary afferents are highly complicated structures, capable of modifying input before it is ever transmitted to the central nervous system and capable of altering the tissue they innervate.
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U2 - 10.1113/jphysiol.2013.269654
DO - 10.1113/jphysiol.2013.269654
M3 - Article
C2 - 24879874
AN - SCOPUS:84906087814
SN - 0022-3751
VL - 592
SP - 3403
EP - 3411
JO - Journal of Physiology
JF - Journal of Physiology
IS - 16
ER -