Nocturnal urinary excretion of 6-hydroxymelatonin sulfate in prepubertal major depressive disorder

G. Scott Waterman, Neal D. Ryan, James M. Perel, Ronald E. Dahl, Boris Birmaher, Douglas E. Williamson, Christopher Thomas, Joaquim Puig-Antich

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Levels of the melatonin metabolite, 6-hydroxymelatonin sulfate, were measured in overnight urine from 31 prepubertal children with major depressive disorder and 15 normal control children with very low family loading for affective disorder. The two groups did not differ with regard to their nocturnal excretion of this compound, nor was depressive subgroup identified whose 6-hydroxymelatonin sulfate excretion differed from that of the control group. Previous studies of pineal function in depression are reviewed and discussed in the context of the present investigation.

Original languageEnglish (US)
Pages (from-to)582-590
Number of pages9
JournalBiological Psychiatry
Volume31
Issue number6
DOIs
StatePublished - Mar 15 1992
Externally publishedYes

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Major Depressive Disorder
Sulfates
Melatonin
Mood Disorders
Urine
Depression
Control Groups
6-hydroxymelatonin

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Waterman, G. S., Ryan, N. D., Perel, J. M., Dahl, R. E., Birmaher, B., Williamson, D. E., ... Puig-Antich, J. (1992). Nocturnal urinary excretion of 6-hydroxymelatonin sulfate in prepubertal major depressive disorder. Biological Psychiatry, 31(6), 582-590. https://doi.org/10.1016/0006-3223(92)90244-T

Nocturnal urinary excretion of 6-hydroxymelatonin sulfate in prepubertal major depressive disorder. / Waterman, G. Scott; Ryan, Neal D.; Perel, James M.; Dahl, Ronald E.; Birmaher, Boris; Williamson, Douglas E.; Thomas, Christopher; Puig-Antich, Joaquim.

In: Biological Psychiatry, Vol. 31, No. 6, 15.03.1992, p. 582-590.

Research output: Contribution to journalArticle

Waterman, GS, Ryan, ND, Perel, JM, Dahl, RE, Birmaher, B, Williamson, DE, Thomas, C & Puig-Antich, J 1992, 'Nocturnal urinary excretion of 6-hydroxymelatonin sulfate in prepubertal major depressive disorder', Biological Psychiatry, vol. 31, no. 6, pp. 582-590. https://doi.org/10.1016/0006-3223(92)90244-T
Waterman, G. Scott ; Ryan, Neal D. ; Perel, James M. ; Dahl, Ronald E. ; Birmaher, Boris ; Williamson, Douglas E. ; Thomas, Christopher ; Puig-Antich, Joaquim. / Nocturnal urinary excretion of 6-hydroxymelatonin sulfate in prepubertal major depressive disorder. In: Biological Psychiatry. 1992 ; Vol. 31, No. 6. pp. 582-590.
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