Nocturnal urinary excretion of 6-hydroxymelatonin sulfate in prepubertal major depressive disorder

G. Scott Waterman, Neal D. Ryan, James M. Perel, Ronald E. Dahl, Boris Birmaher, Douglas E. Williamson, Christopher R. Thomas, Joaquim Puig-Antich

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Levels of the melatonin metabolite, 6-hydroxymelatonin sulfate, were measured in overnight urine from 31 prepubertal children with major depressive disorder and 15 normal control children with very low family loading for affective disorder. The two groups did not differ with regard to their nocturnal excretion of this compound, nor was depressive subgroup identified whose 6-hydroxymelatonin sulfate excretion differed from that of the control group. Previous studies of pineal function in depression are reviewed and discussed in the context of the present investigation.

Original languageEnglish (US)
Pages (from-to)582-590
Number of pages9
JournalBiological Psychiatry
Volume31
Issue number6
DOIs
StatePublished - Mar 15 1992
Externally publishedYes

ASJC Scopus subject areas

  • Biological Psychiatry

Fingerprint Dive into the research topics of 'Nocturnal urinary excretion of 6-hydroxymelatonin sulfate in prepubertal major depressive disorder'. Together they form a unique fingerprint.

Cite this