Nodding syndrome-a new hypothesis and new direction for research

Robert Colebunders, Adam Hendy, Miriam Nanyunja, Joseph Francis Wamala, Marieke van Oijen

Research output: Contribution to journalShort survey

19 Citations (Scopus)

Abstract

Nodding syndrome (NS) is an unexplained neurological illness that mainly affects children aged between 5 and 15 years. NS has so far been reported from South Sudan, northern Uganda, and Tanzania, but in spite of extensive investigations, the aetiology remains unknown. We hypothesize that blackflies (Diptera: Simuliidae) infected with Onchocerca volvulus microfilariae may also transmit another pathogen. This may be a novel neurotropic virus or an endosymbiont of the microfilariae, which causes not only NS, but also epilepsy without nodding. This hypothesis addresses many of the questions about NS that researchers have previously been unable to answer. An argument in favour of the hypothesis is the fact that in Uganda, the number of new NS cases decreased (with no new cases reported since 2013) after ivermectin coverage was increased and with the implementation of a programme of aerial spraying and larviciding of the large rivers where blackflies were breeding. If confirmed, our hypothesis will enable new strategies to control NS outbreaks.

Original languageEnglish (US)
Pages (from-to)74-77
Number of pages4
JournalInternational Journal of Infectious Diseases
Volume27
DOIs
StatePublished - Oct 1 2014
Externally publishedYes

Fingerprint

Nodding Syndrome
Simuliidae
Research
Microfilariae
Uganda
Onchocerca volvulus
Ivermectin
Tanzania
Rivers
Diptera
Breeding
Disease Outbreaks
Direction compound
Epilepsy
Research Personnel
Viruses

Keywords

  • Blackflies
  • Epilepsy
  • Nodding syndrome
  • Onchocerca volvulus
  • Onchocerciasis
  • South Sudan
  • Tanzania
  • Uganda

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Medicine(all)

Cite this

Nodding syndrome-a new hypothesis and new direction for research. / Colebunders, Robert; Hendy, Adam; Nanyunja, Miriam; Wamala, Joseph Francis; van Oijen, Marieke.

In: International Journal of Infectious Diseases, Vol. 27, 01.10.2014, p. 74-77.

Research output: Contribution to journalShort survey

Colebunders, Robert ; Hendy, Adam ; Nanyunja, Miriam ; Wamala, Joseph Francis ; van Oijen, Marieke. / Nodding syndrome-a new hypothesis and new direction for research. In: International Journal of Infectious Diseases. 2014 ; Vol. 27. pp. 74-77.
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