'Non-criteria' aPL tests: Report of a task force and preconference workshop at the 13th International Congress on Antiphospholipid Antibodies, Galveston, TX, USA, April 2010

M. L. Bertolaccini, O. Amengual, T. Atsumi, W. L. Binder, B. De Laat, R. Forastiero, W. H. Kutteh, M. Lambert, H. Matsubayashi, V. Murthy, M. Petri, J. H. Rand, M. Sanmarco, A. E. Tebo, S. S. Pierangeli

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101 Scopus citations

Abstract

Current classification criteria for definite APS recommend the use of one or more of three positive standardized laboratory assays, including anticardiolipin antibodies (aCL), lupus anticoagulant (LA), and antibodies directed to β2glycoprotein I (anti-β2GPI) to detect antiphospholipid antibodies (aPL) in the presence of at least one of the two major clinical manifestations (i.e., thrombosis or pregnancy morbidity) of the syndrome. Several other autoantibodies shown to be directed to phospholipids and/or their complexes with phospholipids and/or to proteins of the coagulation cascade, as well as a mechanistic test for resistance to annexin A5 anticoagulant activity, have been proposed to be relevant to APS. A task force of worldwide scientists in the field discussed and analyzed critical questions related to 'non-criteria' aPL tests in an evidence-based manner during the 13th International Congress on Antiphospholipid Antibodies (APLA 2010, 13-16 April 2010, Galveston, Texas, USA). This report summarizes the findings, conclusions, and recommendations of this task force.

Original languageEnglish (US)
Pages (from-to)191-205
Number of pages15
JournalLupus
Volume20
Issue number2
DOIs
StatePublished - Feb 2011

Keywords

  • IgA
  • autoantibodies
  • phosphatidylethanolamine
  • prothrombin

ASJC Scopus subject areas

  • Rheumatology

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    Bertolaccini, M. L., Amengual, O., Atsumi, T., Binder, W. L., De Laat, B., Forastiero, R., Kutteh, W. H., Lambert, M., Matsubayashi, H., Murthy, V., Petri, M., Rand, J. H., Sanmarco, M., Tebo, A. E., & Pierangeli, S. S. (2011). 'Non-criteria' aPL tests: Report of a task force and preconference workshop at the 13th International Congress on Antiphospholipid Antibodies, Galveston, TX, USA, April 2010. Lupus, 20(2), 191-205. https://doi.org/10.1177/0961203310397082