Non-genomic effects of xenoestrogen mixtures

René Viñas, Yow Jiun Jeng, Cheryl S. Watson

Research output: Contribution to journalReview article

34 Scopus citations

Abstract

Xenoestrogens (XEs) are chemicals derived from a variety of natural and anthropogenic sources that can interfere with endogenous estrogens by either mimicking or blocking their responses via non-genomic and/or genomic signaling mechanisms. Disruption of estrogens' actions through the less-studied non-genomic pathway can alter such functional end points as cell proliferation, peptide hormone release, catecholamine transport, and apoptosis, among others. Studies of potentially adverse effects due to mixtures and to low doses of endocrine-disrupting chemicals have recently become more feasible, though few so far have included actions via the non-genomic pathway. Physiologic estrogens and XEs evoke non-monotonic dose responses, with different compounds having different patterns of actions dependent on concentration and time, making mixture assessments all the more challenging. In order to understand the spectrum of toxicities and their mechanisms, future work should focus on carefully studying individual and mixture components across a range of concentrations and cellular pathways in a variety of tissue types.

Original languageEnglish (US)
Pages (from-to)2694-2714
Number of pages21
JournalInternational Journal of Environmental Research and Public Health
Volume9
Issue number8
DOIs
StatePublished - Aug 1 2012

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Keywords

  • Endocrine-disrupting chemicals
  • Estrogenic mixtures
  • Hormesis
  • Kinases
  • Non-genomic
  • Non-monotonic dose-response curves
  • Xenoestrogens

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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