Non-High-Density Lipoprotein Cholesterol on the Risks of Stroke

A Result from the Kailuan Study

Jianwei Wu, Shengyun Chen, Yong Zhou, Chunxue Wang, Anxin Wang, Qian Zhang, Xiang Gao, Haitao Hu, Shouling Wu, Xingquan Zhao

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Aims:To prospectively explore the association between non-high-density lipoprotein cholesterol (non-HDLC) and the risks of stroke and its subtypes.Methods:A total of 95,916 participants (18-98 years old; 76,354 men and 19,562 women) from a Chinese urban community who were free of myocardial infarction and stroke at baseline time point (2006-2007) were eligible and enrolled in the study. The serum non-HDLC levels of participants were determined by subtracting the high-density lipoprotein cholesterol (HDLC) from total serum cholesterol. The primary outcome was the first occurrence of stroke, which was diagnosed according to the World Health Organization criteria and classified into three subtypes: ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage. The Cox proportional hazards models were used to estimate risk of stroke and its subtypes.Results:During the four-year follow-up, we identified 1614 stroke events (1,156 ischemic, 416 intracerebral hemorrhagic and 42 subarachnoid hemorrhagic). Statistical analyses showed that hazard ratios (HR) (95% Confidence Interval: CI) of serum Non-HDLC level for total and subtypes of stroke were: 1.08 (1.03-1.12) (total), 1.10 (1.05-1.16) (ischemic), 1.03 (0.96-1.10) (intracerebral hemorrhage) and 0.83 (0.66-1.05) (subarachnoid hemorrhage). HR for non-HDLC refers to the increase per each 20 mg/dl. For total and ischemic stroke, the risks were significantly higher in the fourth and fifth quintiles of non-HDLC concentrations compared to the first quintile after adjusting the confounding factors (total stroke: 4th quintile HR=1.33 (1.12-1.59); 5th quintile HR = 1.36 (1.15-1.62); ischemic stroke: 4th quintile HR =1.34 (1.09-1.66); 5th quintile HR = 1.53 (1.24-1.88)).Conclusions:Our data suggest that serum non-HDLC level is an independent risk factor for total and ischemic stroke, and that higher serum non-HDLC concentrations are associated with increased risks for total stroke and ischemic stroke, but not for intracerebral and subarachnoid hemorrhage.

Original languageEnglish (US)
Article numbere74634
JournalPLoS One
Volume8
Issue number9
DOIs
StatePublished - Sep 10 2013
Externally publishedYes

Fingerprint

stroke
lipoproteins
Hazards
Stroke
cholesterol
hemorrhage
Cerebral Hemorrhage
Subarachnoid Hemorrhage
Serum
lipoprotein cholesterol
HDL Cholesterol
Cholesterol
Health
risk estimate
myocardial infarction
World Health Organization
Proportional Hazards Models
high density lipoprotein cholesterol
confidence interval
risk factors

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Wu, J., Chen, S., Zhou, Y., Wang, C., Wang, A., Zhang, Q., ... Zhao, X. (2013). Non-High-Density Lipoprotein Cholesterol on the Risks of Stroke: A Result from the Kailuan Study. PLoS One, 8(9), [e74634]. https://doi.org/10.1371/journal.pone.0074634

Non-High-Density Lipoprotein Cholesterol on the Risks of Stroke : A Result from the Kailuan Study. / Wu, Jianwei; Chen, Shengyun; Zhou, Yong; Wang, Chunxue; Wang, Anxin; Zhang, Qian; Gao, Xiang; Hu, Haitao; Wu, Shouling; Zhao, Xingquan.

In: PLoS One, Vol. 8, No. 9, e74634, 10.09.2013.

Research output: Contribution to journalArticle

Wu, J, Chen, S, Zhou, Y, Wang, C, Wang, A, Zhang, Q, Gao, X, Hu, H, Wu, S & Zhao, X 2013, 'Non-High-Density Lipoprotein Cholesterol on the Risks of Stroke: A Result from the Kailuan Study', PLoS One, vol. 8, no. 9, e74634. https://doi.org/10.1371/journal.pone.0074634
Wu, Jianwei ; Chen, Shengyun ; Zhou, Yong ; Wang, Chunxue ; Wang, Anxin ; Zhang, Qian ; Gao, Xiang ; Hu, Haitao ; Wu, Shouling ; Zhao, Xingquan. / Non-High-Density Lipoprotein Cholesterol on the Risks of Stroke : A Result from the Kailuan Study. In: PLoS One. 2013 ; Vol. 8, No. 9.
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abstract = "Aims:To prospectively explore the association between non-high-density lipoprotein cholesterol (non-HDLC) and the risks of stroke and its subtypes.Methods:A total of 95,916 participants (18-98 years old; 76,354 men and 19,562 women) from a Chinese urban community who were free of myocardial infarction and stroke at baseline time point (2006-2007) were eligible and enrolled in the study. The serum non-HDLC levels of participants were determined by subtracting the high-density lipoprotein cholesterol (HDLC) from total serum cholesterol. The primary outcome was the first occurrence of stroke, which was diagnosed according to the World Health Organization criteria and classified into three subtypes: ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage. The Cox proportional hazards models were used to estimate risk of stroke and its subtypes.Results:During the four-year follow-up, we identified 1614 stroke events (1,156 ischemic, 416 intracerebral hemorrhagic and 42 subarachnoid hemorrhagic). Statistical analyses showed that hazard ratios (HR) (95{\%} Confidence Interval: CI) of serum Non-HDLC level for total and subtypes of stroke were: 1.08 (1.03-1.12) (total), 1.10 (1.05-1.16) (ischemic), 1.03 (0.96-1.10) (intracerebral hemorrhage) and 0.83 (0.66-1.05) (subarachnoid hemorrhage). HR for non-HDLC refers to the increase per each 20 mg/dl. For total and ischemic stroke, the risks were significantly higher in the fourth and fifth quintiles of non-HDLC concentrations compared to the first quintile after adjusting the confounding factors (total stroke: 4th quintile HR=1.33 (1.12-1.59); 5th quintile HR = 1.36 (1.15-1.62); ischemic stroke: 4th quintile HR =1.34 (1.09-1.66); 5th quintile HR = 1.53 (1.24-1.88)).Conclusions:Our data suggest that serum non-HDLC level is an independent risk factor for total and ischemic stroke, and that higher serum non-HDLC concentrations are associated with increased risks for total stroke and ischemic stroke, but not for intracerebral and subarachnoid hemorrhage.",
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AU - Zhou, Yong

AU - Wang, Chunxue

AU - Wang, Anxin

AU - Zhang, Qian

AU - Gao, Xiang

AU - Hu, Haitao

AU - Wu, Shouling

AU - Zhao, Xingquan

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N2 - Aims:To prospectively explore the association between non-high-density lipoprotein cholesterol (non-HDLC) and the risks of stroke and its subtypes.Methods:A total of 95,916 participants (18-98 years old; 76,354 men and 19,562 women) from a Chinese urban community who were free of myocardial infarction and stroke at baseline time point (2006-2007) were eligible and enrolled in the study. The serum non-HDLC levels of participants were determined by subtracting the high-density lipoprotein cholesterol (HDLC) from total serum cholesterol. The primary outcome was the first occurrence of stroke, which was diagnosed according to the World Health Organization criteria and classified into three subtypes: ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage. The Cox proportional hazards models were used to estimate risk of stroke and its subtypes.Results:During the four-year follow-up, we identified 1614 stroke events (1,156 ischemic, 416 intracerebral hemorrhagic and 42 subarachnoid hemorrhagic). Statistical analyses showed that hazard ratios (HR) (95% Confidence Interval: CI) of serum Non-HDLC level for total and subtypes of stroke were: 1.08 (1.03-1.12) (total), 1.10 (1.05-1.16) (ischemic), 1.03 (0.96-1.10) (intracerebral hemorrhage) and 0.83 (0.66-1.05) (subarachnoid hemorrhage). HR for non-HDLC refers to the increase per each 20 mg/dl. For total and ischemic stroke, the risks were significantly higher in the fourth and fifth quintiles of non-HDLC concentrations compared to the first quintile after adjusting the confounding factors (total stroke: 4th quintile HR=1.33 (1.12-1.59); 5th quintile HR = 1.36 (1.15-1.62); ischemic stroke: 4th quintile HR =1.34 (1.09-1.66); 5th quintile HR = 1.53 (1.24-1.88)).Conclusions:Our data suggest that serum non-HDLC level is an independent risk factor for total and ischemic stroke, and that higher serum non-HDLC concentrations are associated with increased risks for total stroke and ischemic stroke, but not for intracerebral and subarachnoid hemorrhage.

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