Non-invasive cardiac output and oxygen delivery measurement in an infant with critical anemia

Garry M. Steil, Olive S. Eckstein, Julie Caplow, Michael S.D. Agus, Brian K. Walsh, Jackson Wong

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Objective: To assess the combination of a non-invasive blood oxygen content (CaO 2) monitor and a non-invasive cardiac output (CO) monitor to continuously measure oxygen delivery (DO 2; DO 2 = CaO 2 × CO). Methods: DO 2 was assessed during blood transfusions in an infant with acute hemolytic anemia following admission (~48 h). CaO 2 was measured by Pulse Co-Oximetry, which also provides estimates of hemoglobin (Hgb) concentration and percent oxygen saturation. CO was measured by Electrical Velocimetry, which also provides an estimate of stroke volume (SV). Lactate levels, an indirect measure of adequate DO 2, were assessed during the initial 8 h following admission. Results: Incremental blood transfusions during the first 36 h increased Hgb from 2.7 to 9.5 g/dL during which time heart rate (HR) normalized from 156 to 115 beats/min. Lactate levels decreased from 20 to 0.8 mmol/L in the first 7 h. Non-invasive Hgb and CaO 2 measurements were well correlated with invasive Hgb and CaO 2 measures (r 2 = 0.88; P = 0.019; r 2 = 0.86; P = 0.0074, respectively). CO decreased from 2.47 ± 0.06 to 1.28 ± 0.02 L/min and SV decreased from 15.9 ± 0.4 to 11.1 ± 0.2 mL/beat. Mean arterial blood pressure was stable throughout the admission with systemic vascular resistance increasing from 407.6 ± 15.2 to 887.7 ± 30.1 dynes-s/cm 5. DO 2 was estimated to increase from 120.2 ± 18.9 to 182.4 ± 5.6 mL O 2/min. Conclusions: Non-invasive contin- uous CO and CaO 2 monitors are shown in this single case to provide continuous DO 2 measurement. The ability to assess DO 2 may improve hemodynamic monitoring during goal directed therapies.

Original languageEnglish (US)
Pages (from-to)113-119
Number of pages7
JournalJournal of Clinical Monitoring and Computing
Issue number2
StatePublished - Apr 2011
Externally publishedYes


  • anemia
  • cardiac output
  • monitoring
  • non-invasive
  • oxygen content
  • oxygen delivery
  • transfusion

ASJC Scopus subject areas

  • Health Informatics
  • Critical Care and Intensive Care Medicine
  • Anesthesiology and Pain Medicine


Dive into the research topics of 'Non-invasive cardiac output and oxygen delivery measurement in an infant with critical anemia'. Together they form a unique fingerprint.

Cite this