Non-mRNA 3′ end formation: How the other half lives

Natoya Peart, Anupama Sataluri, David Baillat, Eric Wagner

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The release of nascent RNA from transcribing RNA polymerase complexes is required for all further functions carried out by RNA molecules. The elements and processing machinery involved in 3′ end formation therefore represent key determinants in the biogenesis and accumulation of cellular RNA. While these factors have been well-characterized for messenger RNA, recent work has elucidated analogous pathways for the 3′ end formation of other important cellular RNA. Here, we discuss four specific cases of non-mRNA 3′ end formation-metazoan small nuclear RNA, Saccharomyces cerevisiae small nuclear RNA, Schizosaccharomyces pombe telomerase RNA, and the mammalian MALAT1 large noncoding RNA-as models of alternative mechanisms to generate RNA 3′ ends. Comparison of these disparate processing pathways reveals an emerging theme of evolutionary ingenuity. In some instances, evidence for the creation of a dedicated processing complex exists; while in others, components are utilized from the existing RNA processing machinery and modified to custom fit the unique needs of the RNA substrate. Regardless of the details of how non-mRNA 3′ ends are formed, the lengths to which biological systems will go to release nascent transcripts from their DNA templates are fundamental for cell survival.

Original languageEnglish (US)
Pages (from-to)491-506
Number of pages16
JournalWiley Interdisciplinary Reviews: RNA
Volume4
Issue number5
DOIs
StatePublished - Sep 2013
Externally publishedYes

Fingerprint

RNA
Small Nuclear RNA
Processing
Machinery
Untranslated RNA
Schizosaccharomyces
Biological systems
DNA-Directed RNA Polymerases
Yeast
Saccharomyces cerevisiae
Cell Survival
Cells
Messenger RNA
Molecules
DNA
Substrates

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Non-mRNA 3′ end formation : How the other half lives. / Peart, Natoya; Sataluri, Anupama; Baillat, David; Wagner, Eric.

In: Wiley Interdisciplinary Reviews: RNA, Vol. 4, No. 5, 09.2013, p. 491-506.

Research output: Contribution to journalArticle

Peart, Natoya ; Sataluri, Anupama ; Baillat, David ; Wagner, Eric. / Non-mRNA 3′ end formation : How the other half lives. In: Wiley Interdisciplinary Reviews: RNA. 2013 ; Vol. 4, No. 5. pp. 491-506.
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