Non-neoplastic inflammatory pseudotumor of the lung after immunotherapy for melanoma: A diagnostic pitfall on fine needle aspiration biopsy of lung

Blessie Elizabeth Nelson, Angelina Hong, Ike Okereke, Avi Markowitz, Maurice Willis, Palawinnage V. Muthukumarana, Ranjana Nawgiri

Research output: Contribution to journalComment/debatepeer-review

Abstract

Nivolumab is commonly used as monotherapy or in combination therapy for management of locally advanced or metastatic melanoma; however, it is also associated with immunotherapy-related adverse events concerning for disease progression or tumor flare reaction. This report presents a case of a non-neoplastic pseudotumor of the lung initially mistaken for malignancy that occurred in a patient receiving adjuvant nivolumab therapy following complete resection of stage IIIB melanoma. The diagnosis was made by lung biopsy and confirmed by a wedge resection, with findings consistent with organizing pneumonia type of pulmonary inflammatory pseudotumor rather than malignancy.

Original languageEnglish (US)
Pages (from-to)1150-1154
Number of pages5
JournalDiagnostic cytopathology
Volume49
Issue number10
DOIs
StatePublished - Oct 2021
Externally publishedYes

Keywords

  • immunotherapy
  • melanoma
  • pseudotumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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