Non-neutralizing Antibodies from a Marburg Infection Survivor Mediate Protection by Fc-Effector Functions and by Enhancing Efficacy of Other Antibodies

Philipp A. Ilinykh, Kai Huang, Rodrigo I. Santos, Pavlo Gilchuk, Bronwyn M. Gunn, Marcus M. Karim, Jenny Liang, Mallorie E. Fouch, Edgar Davidson, Diptiben V. Parekh, James B. Kimble, Colette A. Pietzsch, Michelle Meyer, Natalia A. Kuzmina, Larry Zeitlin, Erica Ollmann Saphire, Galit Alter, James E. Crowe, Alexander Bukreyev

Research output: Contribution to journalArticle

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Abstract

Ilinykh et al. analyzed antibodies from a human survivor of Marburg virus infection and discovered biological properties for non-neutralizing antibodies that protect animals from lethal Marburg virus infection. These include inducing strong Fc domain-mediated effector functions and structural glycoprotein rearrangements that facilitate access of neutralizing antibodies to their recognition sites.

Original languageEnglish (US)
Pages (from-to)976-991.e11
JournalCell Host and Microbe
Volume27
Issue number6
DOIs
StatePublished - Jun 10 2020

Keywords

  • Fc-mediated protective effects
  • Marburg virus
  • animal models of filovirus infection
  • antibodies
  • cooperativity of antibody binding
  • glycoprotein

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology

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  • Cite this

    Ilinykh, P. A., Huang, K., Santos, R. I., Gilchuk, P., Gunn, B. M., Karim, M. M., Liang, J., Fouch, M. E., Davidson, E., Parekh, D. V., Kimble, J. B., Pietzsch, C. A., Meyer, M., Kuzmina, N. A., Zeitlin, L., Saphire, E. O., Alter, G., Crowe, J. E., & Bukreyev, A. (2020). Non-neutralizing Antibodies from a Marburg Infection Survivor Mediate Protection by Fc-Effector Functions and by Enhancing Efficacy of Other Antibodies. Cell Host and Microbe, 27(6), 976-991.e11. https://doi.org/10.1016/j.chom.2020.03.025