@article{714b45dd525144528079a82f1f219933,
title = "Non-neutralizing Antibodies from a Marburg Infection Survivor Mediate Protection by Fc-Effector Functions and by Enhancing Efficacy of Other Antibodies",
abstract = "Ilinykh et al. analyzed antibodies from a human survivor of Marburg virus infection and discovered biological properties for non-neutralizing antibodies that protect animals from lethal Marburg virus infection. These include inducing strong Fc domain-mediated effector functions and structural glycoprotein rearrangements that facilitate access of neutralizing antibodies to their recognition sites.",
keywords = "Fc-mediated protective effects, Marburg virus, animal models of filovirus infection, antibodies, cooperativity of antibody binding, glycoprotein",
author = "Ilinykh, {Philipp A.} and Kai Huang and Santos, {Rodrigo I.} and Pavlo Gilchuk and Gunn, {Bronwyn M.} and Karim, {Marcus M.} and Jenny Liang and Fouch, {Mallorie E.} and Edgar Davidson and Parekh, {Diptiben V.} and Kimble, {James B.} and Pietzsch, {Colette A.} and Michelle Meyer and Kuzmina, {Natalia A.} and Larry Zeitlin and Saphire, {Erica Ollmann} and Galit Alter and Crowe, {James E.} and Alexander Bukreyev",
note = "Funding Information: We thank the UTMB Animal Resource Center veterinary staff for the excellent technical support of in vivo experiments in the ABSL-4. We thank Dr. James Zhu (USDA) for assisting with the peptide microarray. This project was funded by the United States NIH grants U19 AI109711 and U19 AI142785 (to J.E.C. and A.B.) and Defense Threat Reduction Agency grant HDTRA1-13-1-0034 (to J.E.C. and A.B.). NIH contract HHSN 75N93019C00073 supported epitope mapping at Integral Molecular. P.A.I. K.H. R.I.S. P.G. J.E.C. and A.B. planned the studies. P.A.I. K.H. R.I.S. P.G. B.M.G. M.M.K. J.L. M.E.F. E.D. D.V.P. J.B.K. C.A.P. M.M. and N.A.K. conducted experiments. L.Z. provided antibodies. P.A.I. K.H. R.I.S. P.G. B.M.G. E.D. E.O.S. G.A. J.E.C. and A.B. interpreted the studies. P.A.I. and A.B. wrote the first draft of the paper. J.E.C. and A.B. obtained funding. All authors reviewed, edited, and approved the paper. P.A.I. J.E.C. and A.B. are listed as inventors on a submitted patent application, which covers antibodies described in the manuscript. J.E.C. has served as a consultant for Takeda Vaccines, Sanofi-Aventis U.S. Pfizer, and Novavax; is a member of the Scientific Advisory Boards of CompuVax and Meissa Vaccines; and is Founder of IDBiologics. The Crowe laboratory at Vanderbilt University Medical Center has received sponsored research agreements from Moderna, Sanofi-Aventis U.S. and IDBiologics. Funding Information: We thank the UTMB Animal Resource Center veterinary staff for the excellent technical support of in vivo experiments in the ABSL-4. We thank Dr. James Zhu (USDA) for assisting with the peptide microarray. This project was funded by the United States NIH grants U19 AI109711 and U19 AI142785 (to J.E.C. and A.B.) and Defense Threat Reduction Agency grant HDTRA1-13-1-0034 (to J.E.C. and A.B.). NIH contract HHSN 75N93019C00073 supported epitope mapping at Integral Molecular. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = jun,
day = "10",
doi = "10.1016/j.chom.2020.03.025",
language = "English (US)",
volume = "27",
pages = "976--991.e11",
journal = "Cell Host and Microbe",
issn = "1931-3128",
publisher = "Cell Press",
number = "6",
}