Non-neutralizing Antibodies from a Marburg Infection Survivor Mediate Protection by Fc-Effector Functions and by Enhancing Efficacy of Other Antibodies

Philipp A. Ilinykh; Kai Huang; Rodrigo I. Santos; Pavlo Gilchuk; Bronwyn M. Gunn; Marcus M. Karim; Jenny Liang; Mallorie E. Fouch; Edgar Davidson; Diptiben V. Parekh; James Kimble; Colette A. Pietzsch; Michelle Meyer; Natalia A. Kuzmina; Larry Zeitlin; Erica Ollmann Saphire; Galit Alter; James E. Crowe; Alexander Bukreyev

doi:10.1016/j.chom.2020.03.025

Non-neutralizing Antibodies from a Marburg Infection Survivor Mediate Protection by Fc-Effector Functions and by Enhancing Efficacy of Other Antibodies

Philipp A. Ilinykh, Kai Huang, Rodrigo I. Santos, Pavlo Gilchuk, Bronwyn M. Gunn, Marcus M. Karim, Jenny Liang, Mallorie E. Fouch, Edgar Davidson, Diptiben V. Parekh, James Kimble, Colette A. Pietzsch, Michelle Meyer, Natalia A. Kuzmina, Larry Zeitlin, Erica Ollmann Saphire, Galit Alter, James E. Crowe, Alexander Bukreyev

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Ilinykh et al. analyzed antibodies from a human survivor of Marburg virus infection and discovered biological properties for non-neutralizing antibodies that protect animals from lethal Marburg virus infection. These include inducing strong Fc domain-mediated effector functions and structural glycoprotein rearrangements that facilitate access of neutralizing antibodies to their recognition sites.

Original language	English (US)
Pages (from-to)	976-991.e11
Journal	Cell Host and Microbe
Volume	27
Issue number	6
DOIs	https://doi.org/10.1016/j.chom.2020.03.025
State	Published - Jun 10 2020
Externally published	Yes

Keywords

Fc-mediated protective effects
Marburg virus
animal models of filovirus infection
antibodies
cooperativity of antibody binding
glycoprotein

ASJC Scopus subject areas

Parasitology
Microbiology
Virology

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10.1016/j.chom.2020.03.025

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Ilinykh, P. A., Huang, K., Santos, R. I., Gilchuk, P., Gunn, B. M., Karim, M. M., Liang, J., Fouch, M. E., Davidson, E., Parekh, D. V., Kimble, J., Pietzsch, C. A., Meyer, M., Kuzmina, N. A., Zeitlin, L., Saphire, E. O., Alter, G., Crowe, J. E., & Bukreyev, A. (2020). Non-neutralizing Antibodies from a Marburg Infection Survivor Mediate Protection by Fc-Effector Functions and by Enhancing Efficacy of Other Antibodies. Cell Host and Microbe, 27(6), 976-991.e11. https://doi.org/10.1016/j.chom.2020.03.025

Ilinykh, PA, Huang, K, Santos, RI, Gilchuk, P, Gunn, BM, Karim, MM, Liang, J, Fouch, ME, Davidson, E, Parekh, DV, Kimble, J, Pietzsch, CA, Meyer, M, Kuzmina, NA, Zeitlin, L, Saphire, EO, Alter, G, Crowe, JE & Bukreyev, A 2020, 'Non-neutralizing Antibodies from a Marburg Infection Survivor Mediate Protection by Fc-Effector Functions and by Enhancing Efficacy of Other Antibodies', Cell Host and Microbe, vol. 27, no. 6, pp. 976-991.e11. https://doi.org/10.1016/j.chom.2020.03.025

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abstract = "Ilinykh et al. analyzed antibodies from a human survivor of Marburg virus infection and discovered biological properties for non-neutralizing antibodies that protect animals from lethal Marburg virus infection. These include inducing strong Fc domain-mediated effector functions and structural glycoprotein rearrangements that facilitate access of neutralizing antibodies to their recognition sites.",

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author = "Ilinykh, {Philipp A.} and Kai Huang and Santos, {Rodrigo I.} and Pavlo Gilchuk and Gunn, {Bronwyn M.} and Karim, {Marcus M.} and Jenny Liang and Fouch, {Mallorie E.} and Edgar Davidson and Parekh, {Diptiben V.} and James Kimble and Pietzsch, {Colette A.} and Michelle Meyer and Kuzmina, {Natalia A.} and Larry Zeitlin and Saphire, {Erica Ollmann} and Galit Alter and Crowe, {James E.} and Alexander Bukreyev",

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AU - Ilinykh, Philipp A.

AU - Huang, Kai

AU - Santos, Rodrigo I.

AU - Gilchuk, Pavlo

AU - Gunn, Bronwyn M.

AU - Karim, Marcus M.

AU - Liang, Jenny

AU - Fouch, Mallorie E.

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AU - Zeitlin, Larry

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AU - Alter, Galit

AU - Crowe, James E.

AU - Bukreyev, Alexander

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Non-neutralizing Antibodies from a Marburg Infection Survivor Mediate Protection by Fc-Effector Functions and by Enhancing Efficacy of Other Antibodies

Abstract

Keywords

ASJC Scopus subject areas

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