Ilinykh et al. analyzed antibodies from a human survivor of Marburg virus infection and discovered biological properties for non-neutralizing antibodies that protect animals from lethal Marburg virus infection. These include inducing strong Fc domain-mediated effector functions and structural glycoprotein rearrangements that facilitate access of neutralizing antibodies to their recognition sites.
- Fc-mediated protective effects
- Marburg virus
- animal models of filovirus infection
- cooperativity of antibody binding
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