Non-neutralizing Antibodies from a Marburg Infection Survivor Mediate Protection by Fc-Effector Functions and by Enhancing Efficacy of Other Antibodies

Philipp A. Ilinykh, Kai Huang, Rodrigo I. Santos, Pavlo Gilchuk, Bronwyn M. Gunn, Marcus M. Karim, Jenny Liang, Mallorie E. Fouch, Edgar Davidson, Diptiben V. Parekh, James B. Kimble, Colette A. Pietzsch, Michelle Meyer, Natalia A. Kuzmina, Larry Zeitlin, Erica Ollmann Saphire, Galit Alter, James E. Crowe, Alexander Bukreyev

    Research output: Contribution to journalArticlepeer-review

    21 Scopus citations

    Abstract

    Ilinykh et al. analyzed antibodies from a human survivor of Marburg virus infection and discovered biological properties for non-neutralizing antibodies that protect animals from lethal Marburg virus infection. These include inducing strong Fc domain-mediated effector functions and structural glycoprotein rearrangements that facilitate access of neutralizing antibodies to their recognition sites.

    Original languageEnglish (US)
    Pages (from-to)976-991.e11
    JournalCell Host and Microbe
    Volume27
    Issue number6
    DOIs
    StatePublished - Jun 10 2020

    Keywords

    • Fc-mediated protective effects
    • Marburg virus
    • animal models of filovirus infection
    • antibodies
    • cooperativity of antibody binding
    • glycoprotein

    ASJC Scopus subject areas

    • Parasitology
    • Microbiology
    • Virology

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